Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire - PubMed (original) (raw)
. 1994 Sep 29;371(6496):389-95.
doi: 10.1038/371389a0.
Affiliations
- PMID: 7522305
- DOI: 10.1038/371389a0
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
J G Cyster et al. Nature. 1994.
Abstract
Two different approaches to follow clones of B lymphocytes in a diverse preimmune repertoire reveal a new process for eliminating self-reactive cells in the periphery which depends on competition between cells with different specificities. A key feature of this censoring mechanism is the selective exclusion of self-antigen-binding B cells from the normal migration route into lymphoid follicles, resulting in their premature death. This is a striking example of homeostasis by cellular competition for limiting niches and may explain the paradoxical association between immunodeficiency and autoimmunity.
Comment in
- Immunology. How to stop bad B cells.
Nossal GJ. Nossal GJ. Nature. 1994 Sep 29;371(6496):375-6. doi: 10.1038/371375a0. Nature. 1994. PMID: 8090215 No abstract available.
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