Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins - PubMed (original) (raw)
Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins
J W Mulder et al. Lancet. 1994.
Abstract
CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients.
Comment in
- Effect of CD44v6 on survival in colorectal carcinoma.
Koretz K, Möller P, Lehnert T, Hinz U, Otto HF, Herfarth C. Koretz K, et al. Lancet. 1995 Feb 4;345(8945):327-8. doi: 10.1016/s0140-6736(95)90320-8. Lancet. 1995. PMID: 7530795 No abstract available. - Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins.
Finke LH, Terpe HJ, Zörb C, Haensch W, Schlag PM. Finke LH, et al. Lancet. 1995 Mar 4;345(8949):583. Lancet. 1995. PMID: 7539876 No abstract available. - Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins.
Parker D. Parker D. Lancet. 1995 Mar 4;345(8949):583-4. Lancet. 1995. PMID: 7539877 No abstract available.
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