Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells - PubMed (original) (raw)
. 1994 Dec 15;372(6507):691-4.
doi: 10.1038/372691a0.
Affiliations
- PMID: 7527500
- DOI: 10.1038/372691a0
Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells
E M Beckman et al. Nature. 1994.
Abstract
Major histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the alpha beta T-cell antigen receptor (TCR). An analogous antigen-presenting function also has been proposed for the non-MHC-encoded CD1 molecules, a family of non-polymorphic, beta 2-microglobulin-associated glycoproteins expressed on most professional antigen-presenting cells. In support of this hypothesis, CD1 molecules are recognized by selected CD4-CD8- alpha beta or gamma delta TCR+ T-cell clones, and we have recently shown that CD1 molecules restrict the recognition of foreign microbial antigens by alpha beta TCR+ T cells. But the substantial structural divergence of CD1 from MHC class I and class II molecules, raises the possibility that the antigens presented by the CD1 system may differ fundamentally from those presented by MHC-encoded molecules. Here we report that a purified CD1b-restricted antigen of Mycobacterium tuberculosis presented to alpha beta TCR+ T cells is mycolic acid, a family of alpha-branched, beta-hydroxy, long-chain fatty acids found in mycobacteria. This example of non-protein microbial antigen recognition suggests that alpha beta TCR+ T cells recognize a broader range of antigens than previously appreciated and that at least one member of the CD1 family has evolved the ability to present lipid antigens.
Comment in
- Antigen presentation. Chewing the fat.
Parham P. Parham P. Nature. 1994 Dec 15;372(6507):615-6. doi: 10.1038/372615a0. Nature. 1994. PMID: 7527497 No abstract available.
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