Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy - PubMed (original) (raw)
Affiliations
- PMID: 7532474
Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy
R Benelli et al. Oncol Res. 1994.
Abstract
In the initial phases of angiogenesis, endothelial cells must degrade and cross the vessel basement membrane, as do tumor cells during invasion and metastasis formation. Various metalloproteinases have been implicated in tumor cell invasion, in particular MMP-2 (72 kDa collagenase IV, gelatinase A), which has been demonstrated to be associated with tumor metastasis formation. Supernatants from AIDS-Kaposi sarcoma (KS) cells induce normal endothelial cells to invade through a reconstituted basement membrane (Matrigel) in vitro, which correlates with the angiogenic potential of KS cells in vivo. Here we demonstrate that two specific inhibitors of MMP-2, TIMP-2 and a peptide from the MMP-2 propeptide region (peptide 74), inhibit endothelial cell invasion induced by AIDS-KS cell supernatants. Smooth muscle cells were much less sensitive to these inhibitors. These data suggest that MMP-2 activation is a key event in endothelial cell invasion, the initial phase of tumor-associated neoangiogenesis. Inhibition of this enzyme could be an effective treatment for KS and tumor-associated angiogenesis.
Similar articles
- Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness.
Thompson EW, Nakamura S, Shima TB, Melchiori A, Martin GR, Salahuddin SZ, Gallo RC, Albini A. Thompson EW, et al. Cancer Res. 1991 May 15;51(10):2670-6. Cancer Res. 1991. PMID: 2021945 - Inhibition of Kaposi's sarcoma in vivo by fenretinide.
Ferrari N, Morini M, Pfeffer U, Minghelli S, Noonan DM, Albini A. Ferrari N, et al. Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):6020-9. Clin Cancer Res. 2003. PMID: 14676128 - Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro.
Schnaper HW, Grant DS, Stetler-Stevenson WG, Fridman R, D'Orazi G, Murphy AN, Bird RE, Hoythya M, Fuerst TR, French DL, et al. Schnaper HW, et al. J Cell Physiol. 1993 Aug;156(2):235-46. doi: 10.1002/jcp.1041560204. J Cell Physiol. 1993. PMID: 8344982 - The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis.
Ray JM, Stetler-Stevenson WG. Ray JM, et al. Eur Respir J. 1994 Nov;7(11):2062-72. Eur Respir J. 1994. PMID: 7533104 Review. - Matrix metalloproteinase inhibitors.
Wojtowicz-Praga SM, Dickson RB, Hawkins MJ. Wojtowicz-Praga SM, et al. Invest New Drugs. 1997;15(1):61-75. doi: 10.1023/a:1005722729132. Invest New Drugs. 1997. PMID: 9195290 Review.
Cited by
- Molecular mechanisms and clinical management of cancer bone metastasis.
Wang M, Xia F, Wei Y, Wei X. Wang M, et al. Bone Res. 2020 Jul 29;8(1):30. doi: 10.1038/s41413-020-00105-1. eCollection 2020. Bone Res. 2020. PMID: 32793401 Free PMC article. Review. - Role of Matrix Metalloproteinases in the Pathogenesis of Traumatic Brain Injury.
Abdul-Muneer PM, Pfister BJ, Haorah J, Chandra N. Abdul-Muneer PM, et al. Mol Neurobiol. 2016 Nov;53(9):6106-6123. doi: 10.1007/s12035-015-9520-8. Epub 2015 Nov 5. Mol Neurobiol. 2016. PMID: 26541883 Free PMC article. Review. - Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy.
Ammendola M, Leporini C, Marech I, Gadaleta CD, Scognamillo G, Sacco R, Sammarco G, De Sarro G, Russo E, Ranieri G. Ammendola M, et al. Biomed Res Int. 2014;2014:154702. doi: 10.1155/2014/154702. Epub 2014 Sep 11. Biomed Res Int. 2014. PMID: 25295247 Free PMC article. Review. - Targeted therapy for Kaposi sarcoma.
Sullivan RJ, Pantanowitz L, Dezube BJ. Sullivan RJ, et al. BioDrugs. 2009;23(2):69-75. doi: 10.2165/00063030-200923020-00001. BioDrugs. 2009. PMID: 19489649 Free PMC article. Review. - Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma.
Kargiotis O, Chetty C, Gondi CS, Tsung AJ, Dinh DH, Gujrati M, Lakka SS, Kyritsis AP, Rao JS. Kargiotis O, et al. Oncogene. 2008 Aug 14;27(35):4830-40. doi: 10.1038/onc.2008.122. Epub 2008 Apr 28. Oncogene. 2008. PMID: 18438431 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous