B7-1 expression of Langerhans cells is up-regulated by proinflammatory cytokines, and is down-regulated by interferon-gamma or by interleukin-10 - PubMed (original) (raw)
B7-1 expression of Langerhans cells is up-regulated by proinflammatory cytokines, and is down-regulated by interferon-gamma or by interleukin-10
C H Chang et al. Eur J Immunol. 1995 Feb.
Abstract
Langerhans cells (LC) act as potent antigen-presenting cells (APC) for primary and secondary T cell-dependent immune responses. LC express several costimulatory and/or adhesion molecules such as B7/BB1, which has been implicated as one of the important determinants for professional APC. Recent studies have shown that B7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2, and B7-3. We have examined the regulatory properties of B7-1 expression in LC using various cytokines including interleukin (IL)-1 alpha, IL-1 beta, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-10, interferon (IFN)-gamma, granulocyte/macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor (TNF)-alpha. We have demonstrated: 1) that the B7-1 expression of LC is reproducibly up-regulated by either GM-CSF, TNF-alpha, IL-1 alpha, IL-1 beta, or IL-4 in a dose- and time-dependent manner, 2) that GM-CSF exhibits the most active effect on B7-1 up-regulation in each experiment, 3) that IFN-gamma or IL-10 profoundly inhibits the B7-1 expression of LC in a dose- and time-dependent manner, and 4) that the down-regulatory ability of IFN-gamma or IL-10 neutralizes the activity of up-regulatory cytokines. The enhancing or inhibitory action of these cytokines on B7-1 expression occurs selectively because none of the cytokines consistently affects I-A expression of LC. These data suggest that the B7-1 expression of LC may be dynamically regulated by these up- and down-regulatory cytokines in normal and inflammatory epidermal microenvironment.
Similar articles
- Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression.
Ozawa H, Aiba S, Nakagawa, Tagami H. Ozawa H, et al. Eur J Immunol. 1996 Mar;26(3):648-52. doi: 10.1002/eji.1830260321. Eur J Immunol. 1996. PMID: 8605933 - Effects of immunomodulatory cytokines on the presentation of tumor-associated antigens by epidermal Langerhans cells.
Grabbe S, Bruvers S, Granstein RD. Grabbe S, et al. J Invest Dermatol. 1992 Nov;99(5):66S-68S. doi: 10.1111/1523-1747.ep12669018. J Invest Dermatol. 1992. PMID: 1431232 Review. - Cytokine regulation of chemical sensitization.
Kimber I, Holliday MR, Dearman RJ. Kimber I, et al. Toxicol Lett. 1995 Dec;82-83:491-6. doi: 10.1016/0378-4274(95)03497-8. Toxicol Lett. 1995. PMID: 8597100 Review.
Cited by
- Erratum: Type 1 regulatory T cell-mediated tolerance in health and disease.
Frontiers Production Office. Frontiers Production Office. Front Immunol. 2023 Jan 24;13:1125497. doi: 10.3389/fimmu.2022.1125497. eCollection 2022. Front Immunol. 2023. PMID: 36761160 Free PMC article. - Type 1 regulatory T cell-mediated tolerance in health and disease.
Freeborn RA, Strubbe S, Roncarolo MG. Freeborn RA, et al. Front Immunol. 2022 Oct 28;13:1032575. doi: 10.3389/fimmu.2022.1032575. eCollection 2022. Front Immunol. 2022. PMID: 36389662 Free PMC article. Review. - IL-10 as a Th2 Cytokine: Differences Between Mice and Humans.
Rasquinha MT, Sur M, Lasrado N, Reddy J. Rasquinha MT, et al. J Immunol. 2021 Nov 1;207(9):2205-2215. doi: 10.4049/jimmunol.2100565. J Immunol. 2021. PMID: 34663593 Free PMC article. Review. - The combination of IκB kinase β inhibitor and everolimus modulates expression of interleukin-10 in human T-cell lymphotropic virus type-1-infected T cells.
Nishioka C, Ikezoe T, Yang J, Udaka K, Yokoyama A. Nishioka C, et al. Immunology. 2013 Mar;138(3):216-27. doi: 10.1111/imm.12035. Immunology. 2013. PMID: 23278479 Free PMC article. - The yin and yang of human Beta-defensins in health and disease.
Weinberg A, Jin G, Sieg S, McCormick TS. Weinberg A, et al. Front Immunol. 2012 Oct 8;3:294. doi: 10.3389/fimmu.2012.00294. eCollection 2012. Front Immunol. 2012. PMID: 23060878 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous