Expression and distribution of functional integrins in rat CNS glia - PubMed (original) (raw)
. 1994 Nov 1;39(4):436-47.
doi: 10.1002/jnr.490390411.
Affiliations
- PMID: 7533845
- DOI: 10.1002/jnr.490390411
Expression and distribution of functional integrins in rat CNS glia
N J Tawil et al. J Neurosci Res. 1994.
Abstract
In previous studies, we have reported on the expression of beta 1 integrins in type 1 astrocytes and their function in cell-substratum attachment (Tawil et al., J Cell Biol 120:261-271, 1993). Here we extend those findings by providing evidence that type 1 astrocytes express integrins of the beta 3 and possibly beta 4 subclasses and that the former (alpha v beta 3) functions in attachment by recognizing the peptide, Arg-Gly-Asp, in vitronectin. In addition, we have examined immunocytochemically the expression of beta 1 integrins on type 2 astrocytes and oligodendrocytes. The pattern of expression of integrins on these two cell types is distinct from type 1 astrocytes; most notably type 1 astrocytes but not oligodendrocytes or type 2 astrocytes express alpha 1 beta 1 heterodimers. Since type 2 astrocytes and oligodendrocytes originate from a common precursor (O-2A), the alpha 1 beta 1 heterodimer may be a functional marker which distinguishes O-2A-derived cells from those of the type 1 astrocyte lineage.
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