Regulation of the interferon-induced PKR: can viruses cope? - PubMed (original) (raw)
Review
Regulation of the interferon-induced PKR: can viruses cope?
M G Katze. Trends Microbiol. 1995 Feb.
Abstract
Viruses that fail to block the lethal effects of the double-stranded-RNA-activated protein kinase (PKR) may be doomed; why do so many viruses go to so much trouble to downregulate this interferon-induced protein kinase? PKR may regulate cell growth and proliferation in uninfected cells, suggesting that it also participates in the antiproliferative arm of the interferon response.
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