Intermediate filaments in disease - PubMed (original) (raw)
Review
Intermediate filaments in disease
W H McLean et al. Curr Opin Cell Biol. 1995 Feb.
Abstract
Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as providing essential structural support for cells in different physical settings.