Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships - PubMed (original) (raw)
Comparative Study
. 1995 Jun 15;211(2):375-81.
doi: 10.1006/bbrc.1995.1824.
Affiliations
- PMID: 7540837
- DOI: 10.1006/bbrc.1995.1824
Comparative Study
Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships
L Kobzik et al. Biochem Biophys Res Commun. 1995.
Abstract
Immunohistochemistry shows that skeletal muscle fibers express endothelial-type (ec)-NOS in a heterogeneous pattern distinct from that of neuronal (nc)-NOS. Analysis of adjacent serial sections reveals: 1) a strong correlation of ec-NOS expression to mitochondrial content (visualized histochemically by succinate dehydrogenase); 2) lack of correlation of ec-NOS to fiber ATPase type (in contrast to nc-NOS); and 3) constitutive co-expression of ec- and nc-NOS in some fibers. Preparations of mitochondria from diaphragm exhibited calcium-dependent NOS activity, which functioned to inhibit in vitro oxygen consumption. The results establish that normal skeletal muscle cells can express two constitutive isoforms of NOS (nc- and ec-) and suggest a functional role for ec-NOS in oxidative, mitochondria-rich fibers.
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