Rho as a regulator of the cytoskeleton - PubMed (original) (raw)
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Rho as a regulator of the cytoskeleton
Y Takai et al. Trends Biochem Sci. 1995 Jun.
Abstract
Many cell functions, including maintenance of morphology, aggregation, motility, membrane ruffling, smooth-muscle contraction, cytokinesis in mammals and bud formation in yeast, are regulated through the dynamic reorganization of actin filaments. Although it has long been known that Ca2+ is a key regulator of the cytoskeleton, evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions.
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