Analysis of human immunodeficiency virus type 1 integrase mutants - PubMed (original) (raw)
. 1995 Aug 1;211(1):332-5.
doi: 10.1006/viro.1995.1412.
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- PMID: 7544046
- DOI: 10.1006/viro.1995.1412
Free article
Analysis of human immunodeficiency virus type 1 integrase mutants
M A Ansari-Lari et al. Virology. 1995.
Free article
Erratum in
- Analysis of human immunodeficiency virus type 1 integrase mutants.
Ansari-Lari MA, Donehower LA, Gibbs RA. Ansari-Lari MA, et al. Virology. 1995 Nov 10;213(2):680. Virology. 1995. PMID: 7491794 No abstract available.
Abstract
The human immunodeficiency virus type-1 (HIV-1) integrase protein (IN) mediates the insertion of linear double-stranded viral DNA into the host genome. Mutations in IN can have different effects on the virus life cycle. In this study, Gag-Pol polyprotein processing, Tat synthesis, and viral replication were investigated in integrase-defective HIV-1 mutants. In the absence of IN synthesis, the Gag-Pol polyprotein stability, packaging, and/or processing was reduced. There was limited expression of Tat observed in IN mutants, but no viral replication.
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