Sleep as neuronal detoxification and restitution - PubMed (original) (raw)
Review
Sleep as neuronal detoxification and restitution
S Inoué et al. Behav Brain Res. 1995 Jul-Aug.
Abstract
The classical 'hypnotoxin theory' was followed by extensive search for an endogenous sleep substance. Brain tissues and body fluids of sleeping and sleep-deprived animals contained active sleep-inducing factors like the sleep-promoting substance (SPS). Uridine and oxidized glutathione (GSSG), two components of SPS, seem to regulate physiological sleep differentially. Uridine may facilitate the inhibitory neurotransmission at the synaptic level of the GABAA-uridine receptor complex. In contrast, GSSG may inhibit the excitatory neurotransmission at the synaptic level of the glutamate receptor. Thus, the two SPS components promote sleep by exerting a complementary action on the two major neurotransmitter systems in the brain that have mutually reciprocal functions. Further, among multidimensional functions of sleep, uridine may contribute to recover the activity of neurons, while glutathione may counteract excitotoxic events. Hence sleep at the behavioral level is a process of neuronal restitution and detoxification at the cellular level. Such a concept can be regarded as a modern version of the Ishimori-Piéron's hypnotoxin theory proposed early in this century.
Similar articles
- SPS-B, a physiological sleep regulator, from the brainstems of sleep-deprived rats, identified as oxidized glutathione.
Komoda Y, Honda K, Inoue S. Komoda Y, et al. Chem Pharm Bull (Tokyo). 1990 Jul;38(7):2057-9. doi: 10.1248/cpb.38.2057. Chem Pharm Bull (Tokyo). 1990. PMID: 2268912 - Oxidized glutathione regulates physiological sleep in unrestrained rats.
Honda K, Komoda Y, Inoué S. Honda K, et al. Brain Res. 1994 Feb 14;636(2):253-8. doi: 10.1016/0006-8993(94)91024-3. Brain Res. 1994. PMID: 8012809 - [Sleep-promoting substances].
Fujitani Y, Urade Y, Hayaishi O. Fujitani Y, et al. Nihon Ronen Igakkai Zasshi. 1998 Nov;35(11):811-6. doi: 10.3143/geriatrics.35.811. Nihon Ronen Igakkai Zasshi. 1998. PMID: 10064966 Review. Japanese. No abstract available. - Uridine receptor: discovery and its involvement in sleep mechanism.
Kimura T, Ho IK, Yamamoto I. Kimura T, et al. Sleep. 2001 May 1;24(3):251-60. doi: 10.1093/sleep/24.3.251. Sleep. 2001. PMID: 11322706 Review. - [Neurochemical mechanisms of sleep regulation].
[No authors listed] [No authors listed] Glas Srp Akad Nauka Med. 2009;(50):97-109. Glas Srp Akad Nauka Med. 2009. PMID: 20666118 Review. Serbian.
Cited by
- Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats.
Guzmán-Marín R, Suntsova N, Stewart DR, Gong H, Szymusiak R, McGinty D. Guzmán-Marín R, et al. J Physiol. 2003 Jun 1;549(Pt 2):563-71. doi: 10.1113/jphysiol.2003.041665. Epub 2003 Apr 4. J Physiol. 2003. PMID: 12679377 Free PMC article. - How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults.
Gadie A, Shafto M, Leng Y, Kievit RA; Cam-CAN. Gadie A, et al. BMJ Open. 2017 Jul 31;7(7):e014920. doi: 10.1136/bmjopen-2016-014920. BMJ Open. 2017. PMID: 28760786 Free PMC article. - Effect of REM sleep deprivation on the antioxidant status in the brain of Wistar rats.
Mathangi DC, Shyamala R, Subhashini AS. Mathangi DC, et al. Ann Neurosci. 2012 Oct;19(4):161-4. doi: 10.5214/ans.0972.7531.190405. Ann Neurosci. 2012. PMID: 25205991 Free PMC article. - The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress Conditions.
Piedrafita G, Keller MA, Ralser M. Piedrafita G, et al. Biomolecules. 2015 Sep 10;5(3):2101-22. doi: 10.3390/biom5032101. Biomolecules. 2015. PMID: 26378592 Free PMC article. Review. - Different Effects of Sleep Deprivation and Torpor on EEG Slow-Wave Characteristics in Djungarian Hamsters.
Vyazovskiy VV, Palchykova S, Achermann P, Tobler I, Deboer T. Vyazovskiy VV, et al. Cereb Cortex. 2017 Feb 1;27(2):950-961. doi: 10.1093/cercor/bhx020. Cereb Cortex. 2017. PMID: 28168294 Free PMC article.