Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration - PubMed (original) (raw)
Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration
M A Kay et al. Nat Genet. 1995 Oct.
Abstract
Recombinant adenovirus vectors are efficient at transferring genes into somatic tissues but are limited for use in clinical gene therapy by immunologic factors that result in the rapid loss of gene expression and inhibit secondary gene transfer. This study demonstrates that systemic coadministration of recombinant adenovirus with soluble CTLA4Ig, which is known to block co-stimulatory signals between T cells and antigen presenting cells, leads to persistent adenoviral gene expression in mice without long-term immunosuppression. This form of immunotherapy greatly enhances the likelihood that recombinant adenovirus vectors will be useful for human gene therapy.
Similar articles
- Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression.
Schowalter DB, Meuse L, Wilson CB, Linsley PS, Kay MA. Schowalter DB, et al. Gene Ther. 1997 Aug;4(8):853-60. doi: 10.1038/sj.gt.3300466. Gene Ther. 1997. PMID: 9338015 - Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.
Kay MA, Meuse L, Gown AM, Linsley P, Hollenbaugh D, Aruffo A, Ochs HD, Wilson CB. Kay MA, et al. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4686-91. doi: 10.1073/pnas.94.9.4686. Proc Natl Acad Sci U S A. 1997. PMID: 9114052 Free PMC article. - Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle.
Jiang ZL, Reay D, Kreppel F, Gambotto A, Feingold E, Kochanek S, McCarthy SA, Clemens PR. Jiang ZL, et al. Mol Ther. 2001 Jun;3(6):892-900. doi: 10.1006/mthe.2001.0331. Mol Ther. 2001. PMID: 11407903 - Immunopathology and the gene therapy of lupus.
Mageed RA, Prud'homme GJ. Mageed RA, et al. Gene Ther. 2003 May;10(10):861-74. doi: 10.1038/sj.gt.3302016. Gene Ther. 2003. PMID: 12732872 Review. - Local immunomodulation to promote co-stimulatory blockade.
Chahine AA, Stoeckert C, Lau HT. Chahine AA, et al. Clin Transplant. 1995 Jun;9(3 Pt 2):215-8. Clin Transplant. 1995. PMID: 7670166 Review. No abstract available.
Cited by
- Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues.
Yang Y, Su Q, Grewal IS, Schilz R, Flavell RA, Wilson JM. Yang Y, et al. J Virol. 1996 Sep;70(9):6370-7. doi: 10.1128/JVI.70.9.6370-6377.1996. J Virol. 1996. PMID: 8709265 Free PMC article. - Gene therapy for lung inflammatory diseases: not so far away?
Sallenave JM, Porteous DJ, Haslett C. Sallenave JM, et al. Thorax. 1997 Aug;52(8):742-4. doi: 10.1136/thx.52.8.742. Thorax. 1997. PMID: 9337837 Free PMC article. - RGD peptide-modified adenovirus expressing hepatocyte growth factor and X-linked inhibitor of apoptosis improves islet transplantation.
Wu H, Yoon AR, Li F, Yun CO, Mahato RI. Wu H, et al. J Gene Med. 2011 Dec;13(12):658-69. doi: 10.1002/jgm.1626. J Gene Med. 2011. PMID: 22095898 Free PMC article. - An important role for major histocompatibility complex class I-restricted T cells, and a limited role for gamma interferon, in protection of mice against lethal herpes simplex virus infection.
Holterman AX, Rogers K, Edelmann K, Koelle DM, Corey L, Wilson CB. Holterman AX, et al. J Virol. 1999 Mar;73(3):2058-63. doi: 10.1128/JVI.73.3.2058-2063.1999. J Virol. 1999. PMID: 9971787 Free PMC article. - Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity.
Schulick AH, Vassalli G, Dunn PF, Dong G, Rade JJ, Zamarron C, Dichek DA. Schulick AH, et al. J Clin Invest. 1997 Jan 15;99(2):209-19. doi: 10.1172/JCI119149. J Clin Invest. 1997. PMID: 9005989 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources