Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals - PubMed (original) (raw)
Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals
A Bonni et al. Mol Cell Neurosci. 1995 Apr.
Free article
Abstract
A mechanism has been characterized by which the transcription factor CREB regulates neurotrophin-induced gene expression. Whereas CREB can mediate calcium- or cyclic AMP-induced c-fos transcription independently of other promoter-bound transcription factors, CREB mediates NGF induction of c-fos transcription via a novel mechanism that appears to require a cooperative interaction with another transcription factor, the serum response factor. A similar transcriptional mechanism may explain how neurotrophins and growth factors induce distinct subsets of delayed response genes. Neurotrophins induce the phosphorylation of CREB at a key regulatory site, Serine 133, with prolonged kinetics that are distinct from the transient kinetics of CREB phosphorylation elicited by growth factors. These results indicate that CREB is a versatile transcription factor that activates transcription via distinct mechanisms in a stimulus-specific manner. In addition, by selectively activating delayed response genes, CREB may confer specificity to neurotrophin signals that promote the survival and differentiation of neurons.
Similar articles
- ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element.
Guo B, Stein JL, van Wijnen AJ, Stein GS. Guo B, et al. Biochemistry. 1997 Nov 25;36(47):14447-55. doi: 10.1021/bi971781s. Biochemistry. 1997. PMID: 9398163 - CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes.
Hsueh YP, Liang HE, Ng SY, Lai MZ. Hsueh YP, et al. J Immunol. 1997 Jan 1;158(1):85-93. J Immunol. 1997. PMID: 8977178 - Transcriptional regulation in response to exercise.
Baar K, Blough E, Dineen B, Esser K. Baar K, et al. Exerc Sport Sci Rev. 1999;27:333-79. Exerc Sport Sci Rev. 1999. PMID: 10791022 Review. - Calcium regulation of gene expression: isn't that spatial?
Ginty DD. Ginty DD. Neuron. 1997 Feb;18(2):183-6. doi: 10.1016/s0896-6273(00)80258-5. Neuron. 1997. PMID: 9052789 Review. No abstract available.
Cited by
- Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes.
Ruggiero C, Lalli E. Ruggiero C, et al. Front Endocrinol (Lausanne). 2016 Mar 29;7:24. doi: 10.3389/fendo.2016.00024. eCollection 2016. Front Endocrinol (Lausanne). 2016. PMID: 27065945 Free PMC article. Review. - Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling.
Liu CM, Hur EM, Zhou FQ. Liu CM, et al. Front Mol Neurosci. 2012 Feb 6;5:3. doi: 10.3389/fnmol.2012.00003. eCollection 2012. Front Mol Neurosci. 2012. PMID: 22347166 Free PMC article. - Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity.
Kalita K, Kharebava G, Zheng JJ, Hetman M. Kalita K, et al. J Neurosci. 2006 Sep 27;26(39):10020-32. doi: 10.1523/JNEUROSCI.2644-06.2006. J Neurosci. 2006. PMID: 17005865 Free PMC article. - SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells.
Luo YR, Kudo TA, Tominami K, Izumi S, Tanaka T, Hayashi Y, Noguchi T, Matsuzawa A, Nakai J, Hong G, Wang H. Luo YR, et al. Int J Mol Sci. 2022 Dec 9;23(24):15602. doi: 10.3390/ijms232415602. Int J Mol Sci. 2022. PMID: 36555248 Free PMC article. - Effects of substrate stiffness and cell density on primary hippocampal cultures.
Previtera ML, Langhammer CG, Firestein BL. Previtera ML, et al. J Biosci Bioeng. 2010 Oct;110(4):459-70. doi: 10.1016/j.jbiosc.2010.04.004. Epub 2010 May 10. J Biosci Bioeng. 2010. PMID: 20547372 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources