Signalling downstream of activated mammalian Notch - PubMed (original) (raw)

. 1995 Sep 28;377(6547):355-8.

doi: 10.1038/377355a0.

Affiliations

• PMID: 7566092
• DOI: 10.1038/377355a0

Signalling downstream of activated mammalian Notch

S Jarriault et al. Nature. 1995.

Abstract

Notch belongs to a family of transmembrane proteins that are widely conserved from flies to vertebrates and are thought to be involved in cell-fate decisions. In Drosophila, the Suppressor of hairless (Su(H)) gene and genes of the Enhancer of split (E(Spl)) complex, which encode proteins of the basic helix-loop-helix type have been implicated in the Notch signalling pathway. Mammalian homologues of E(Spl), such as the mouse Hairy enhancer of split (HES-1), have been isolated. Both HES-1 and the intracellular domain of murine Notch (mNotch) are able to block MyoD-induced myogenesis. Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-J kappa (refs 8,9) and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter.

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Comment in

• Signal transduction. Notch takes a short cut.
  Goodbourn S. Goodbourn S. Nature. 1995 Sep 28;377(6547):288-9. doi: 10.1038/377288a0. Nature. 1995. PMID: 7566081 No abstract available.

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