Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor - PubMed (original) (raw)

. 1995 Oct 5;377(6548):397-404.

doi: 10.1038/377397a0.

Affiliations

• PMID: 7566114
• DOI: 10.1038/377397a0

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

A J Hörlein et al. Nature. 1995.

Abstract

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

PubMed Disclaimer

Comment in

• The sound of silence.
  Perlmann T, Vennström B. Perlmann T, et al. Nature. 1995 Oct 5;377(6548):387-8. doi: 10.1038/377387a0. Nature. 1995. PMID: 7566111 No abstract available.

Similar articles

• A transcriptional co-repressor that interacts with nuclear hormone receptors.
  Chen JD, Evans RM. Chen JD, et al. Nature. 1995 Oct 5;377(6548):454-7. doi: 10.1038/377454a0. Nature. 1995. PMID: 7566127
• Modulation of thyroid hormone receptor silencing function by co-repressors and a synergizing transcription factor.
  Lutz M, Baniahmad A, Renkawitz R. Lutz M, et al. Biochem Soc Trans. 2000;28(4):386-9. Biochem Soc Trans. 2000. PMID: 10961925 Review.
• A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
  Heinzel T, Lavinsky RM, Mullen TM, Söderstrom M, Laherty CD, Torchia J, Yang WM, Brard G, Ngo SD, Davie JR, Seto E, Eisenman RN, Rose DW, Glass CK, Rosenfeld MG. Heinzel T, et al. Nature. 1997 May 1;387(6628):43-8. doi: 10.1038/387043a0. Nature. 1997. PMID: 9139820
• Polarity-specific activities of retinoic acid receptors determined by a co-repressor.
  Kurokawa R, Söderström M, Hörlein A, Halachmi S, Brown M, Rosenfeld MG, Glass CK. Kurokawa R, et al. Nature. 1995 Oct 5;377(6548):451-4. doi: 10.1038/377451a0. Nature. 1995. PMID: 7566126
• Structure and function of nuclear hormone receptors.
  Parker MG. Parker MG. Semin Cancer Biol. 1990 Feb;1(1):81-7. Semin Cancer Biol. 1990. PMID: 1966791 Review.

Cited by

• Peroxisome Proliferator-Activated Receptors and Caloric Restriction-Common Pathways Affecting Metabolism, Health, and Longevity.
  Duszka K, Gregor A, Guillou H, König J, Wahli W. Duszka K, et al. Cells. 2020 Jul 16;9(7):1708. doi: 10.3390/cells9071708. Cells. 2020. PMID: 32708786 Free PMC article. Review.
• Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.
  Wang Y, Zhang B, Wang J, Wu H, Xu S, Zhang J, Wang L. Wang Y, et al. Cell Commun Signal. 2021 Mar 24;19(1):40. doi: 10.1186/s12964-021-00729-8. Cell Commun Signal. 2021. PMID: 33761934 Free PMC article.
• Natural compounds targeting nuclear receptors for effective cancer therapy.
  Hegde M, Girisa S, Naliyadhara N, Kumar A, Alqahtani MS, Abbas M, Mohan CD, Warrier S, Hui KM, Rangappa KS, Sethi G, Kunnumakkara AB. Hegde M, et al. Cancer Metastasis Rev. 2023 Sep;42(3):765-822. doi: 10.1007/s10555-022-10068-w. Epub 2022 Dec 8. Cancer Metastasis Rev. 2023. PMID: 36482154 Review.
• Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis.
  Kumar S, Cunningham TJ, Duester G. Kumar S, et al. Dev Biol. 2016 Oct 1;418(1):204-215. doi: 10.1016/j.ydbio.2016.08.005. Epub 2016 Aug 6. Dev Biol. 2016. PMID: 27506116 Free PMC article.
• A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
  Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG, Glass CK. Pascual G, et al. Nature. 2005 Sep 29;437(7059):759-63. doi: 10.1038/nature03988. Epub 2005 Aug 28. Nature. 2005. PMID: 16127449 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Guide to Pharmacology
  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program