Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor - PubMed (original) (raw)

. 1995 Oct 5;377(6548):397-404.

doi: 10.1038/377397a0.

Affiliations

• PMID: 7566114
• DOI: 10.1038/377397a0

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

A J Hörlein et al. Nature. 1995.

Abstract

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

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Comment in

• The sound of silence.
  Perlmann T, Vennström B. Perlmann T, et al. Nature. 1995 Oct 5;377(6548):387-8. doi: 10.1038/377387a0. Nature. 1995. PMID: 7566111 No abstract available.

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