Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II) - PubMed (original) (raw)

Comparative Study

. 1995 Nov;72(5):1189-93.

doi: 10.1038/bjc.1995.484.

Affiliations

Free PMC article

Comparative Study

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

P Bates et al. Br J Cancer. 1995 Nov.

Free PMC article

Abstract

The effect of insulin-like growth factor II (IGF-II) on tumour development in the mouse mammary gland was studied. To promote extra IGF-II expression in the mammary gland, sheep beta-lactoglobulin regulatory elements were attached to the coding regions of the mouse Igf-2 gene and injected into the pronuclei of mouse zygotes. Mammary tumours developed in each of the four independent lines of mice which expressed transgene IGF-II in the gland. Tumours from two of the lines grew after transplantation to both male and female hosts. Primary tumours contained stromal and epithelial regions, but the tumours were dominated by mammary adenocarcinoma after transplantation. The tumours expressed high levels of Igf-2 mRNA transcribed from the integrated transgenes.

PubMed Disclaimer

Comment in

References

    1. Science. 1976 Dec 24;194(4272):1439-41 - PubMed
    1. Nucleic Acids Res. 1984 Sep 25;12(18):7035-56 - PubMed
    1. J Hered. 1986 May-Jun;77(3):151-8 - PubMed
    1. Am J Clin Nutr. 1987 Jan;45(1 Suppl):168-80 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Feb;84(4):1104-6 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources