A family of murine NK cell receptors specific for target cell MHC class I molecules - PubMed (original) (raw)
Review
A family of murine NK cell receptors specific for target cell MHC class I molecules
W M Yokoyama et al. Semin Immunol. 1995 Apr.
Abstract
The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+ NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.
Similar articles
- Role of conserved glycosylation site unique to murine class I MHC in recognition by Ly-49 NK cell receptor.
Lian RH, Freeman JD, Mager DL, Takei F. Lian RH, et al. J Immunol. 1998 Sep 1;161(5):2301-6. J Immunol. 1998. PMID: 9725224 - The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells.
Ortaldo JR, Winkler-Pickett R, Mason AT, Mason LH. Ortaldo JR, et al. J Immunol. 1998 Feb 1;160(3):1158-65. J Immunol. 1998. PMID: 9570529 - The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.
Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. Sundbäck J, et al. J Immunol. 1998 Jun 15;160(12):5971-8. J Immunol. 1998. PMID: 9637511 - NK cell recognition of major histocompatibility complex class I molecules.
Lanier LL, Phillips JH. Lanier LL, et al. Semin Immunol. 1995 Apr;7(2):75-82. doi: 10.1006/smim.1995.0011. Semin Immunol. 1995. PMID: 7579197 Review. - The murine Ly49 family: form and function.
Makrigiannis AP, Anderson SK. Makrigiannis AP, et al. Arch Immunol Ther Exp (Warsz). 2001;49(1):47-50. Arch Immunol Ther Exp (Warsz). 2001. PMID: 11266090 Review.
Cited by
- Natural killer cell immune responses.
Yokoyama WM. Yokoyama WM. Immunol Res. 2005;32(1-3):317-25. doi: 10.1385/IR:32:1-3:317. Immunol Res. 2005. PMID: 16106081 Review. - Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation.
Rodriguez-Barbosa JI, Ferreras MC, Buhler L, Jones ND, Schneider P, Perez-Simon JA, Del Rio ML. Rodriguez-Barbosa JI, et al. MAbs. 2018 Oct;10(7):1030-1044. doi: 10.1080/19420862.2018.1502127. Epub 2018 Sep 5. MAbs. 2018. PMID: 30036156 Free PMC article. - Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation.
Park A, Lee Y, Kim MS, Kang YJ, Park YJ, Jung H, Kim TD, Lee HG, Choi I, Yoon SR. Park A, et al. Front Immunol. 2018 Aug 9;9:1859. doi: 10.3389/fimmu.2018.01859. eCollection 2018. Front Immunol. 2018. PMID: 30140269 Free PMC article. - The mother-child union: the case of missing-self and protection of the fetus.
Yokoyama WM. Yokoyama WM. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):5998-6000. doi: 10.1073/pnas.94.12.5998. Proc Natl Acad Sci U S A. 1997. PMID: 9177157 Free PMC article. Review. No abstract available. - Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE.
Katz HR, Vivier E, Castells MC, McCormick MJ, Chambers JM, Austen KF. Katz HR, et al. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10809-14. doi: 10.1073/pnas.93.20.10809. Proc Natl Acad Sci U S A. 1996. PMID: 8855262 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials