TCR-associated zeta-Fc epsilon RI gamma heterodimers on CD4-CD8- NK1.1+ T cells selected by specific class I MHC antigen - PubMed (original) (raw)
TCR-associated zeta-Fc epsilon RI gamma heterodimers on CD4-CD8- NK1.1+ T cells selected by specific class I MHC antigen
S J Curnow et al. Immunity. 1995 Oct.
Free article
Abstract
The origin of autoreactive CD4-CD8- T cells is largely unknown. In TCR transgenic (Tg) mice expressing the cognate class I MHC antigen, CD4-CD8- T cells differed depending on characteristics of Tg-TCR/antigen interaction. Tg-TCR/CD3lo CD4-CD8- T cells expressing the NK1.1 marker were observed only for a Tg-TCR whose stimulation by antigen was independent of CD8. Unlike normal T cells, which have essentially TCR-associated zeta homodimers, these cells had a high proportion of TCR-associated zeta-Fc epsilon RI gamma heterodimers. They were also characterized by an unusually high content of Fc epsilon RI gamma mRNA and low content of mRNA encoding CD3 epsilon, CD3 gamma, CD3 delta, and zeta. Based on their phenotype and selection requirements, it is proposed that CD4-CD8- thymic precursor cells can be driven along the CD4-CD8-NK1.1+ pathway following coreceptor-independent TCR signaling at an intrathymic stage when Fc epsilon RI gamma and CD3 components are coexpressed.
Similar articles
- CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells.
Koyasu S. Koyasu S. J Exp Med. 1994 Jun 1;179(6):1957-72. doi: 10.1084/jem.179.6.1957. J Exp Med. 1994. PMID: 8195719 Free PMC article. - Selection of peripheral and intestinal T lymphocytes lacking CD3 zeta.
Simpson S, Holländer G, She J, Levelt C, Huang M, Terhorst C. Simpson S, et al. Int Immunol. 1995 Feb;7(2):287-93. doi: 10.1093/intimm/7.2.287. Int Immunol. 1995. PMID: 7734423 - TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen.
Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, Bluestone JA. Khattri R, et al. J Immunol. 1996 Sep 15;157(6):2320-7. J Immunol. 1996. PMID: 8805629 - Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling.
Julius M, Maroun CR, Haughn L. Julius M, et al. Immunol Today. 1993 Apr;14(4):177-83. doi: 10.1016/0167-5699(93)90282-p. Immunol Today. 1993. PMID: 8499078 Review. - Interplay between the TCR/CD3 complex and CD4 or CD8 in the activation of cytotoxic T lymphocytes.
de Vries JE, Yssel H, Spits H. de Vries JE, et al. Immunol Rev. 1989 Jun;109:119-41. doi: 10.1111/j.1600-065x.1989.tb00022.x. Immunol Rev. 1989. PMID: 2527803 Review.
Cited by
- Structural insights into the high-affinity IgE receptor FcεRI complex.
Deng M, Du S, Hou H, Xiao J. Deng M, et al. Nature. 2024 Sep;633(8031):952-959. doi: 10.1038/s41586-024-07864-5. Epub 2024 Aug 21. Nature. 2024. PMID: 39169187 - Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets.
Georgiev H, Ravens I, Benarafa C, Förster R, Bernhardt G. Georgiev H, et al. Nat Commun. 2016 Oct 10;7:13116. doi: 10.1038/ncomms13116. Nat Commun. 2016. PMID: 27721447 Free PMC article. - CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells.
Chun T, Page MJ, Gapin L, Matsuda JL, Xu H, Nguyen H, Kang HS, Stanic AK, Joyce S, Koltun WA, Chorney MJ, Kronenberg M, Wang CR. Chun T, et al. J Exp Med. 2003 Apr 7;197(7):907-18. doi: 10.1084/jem.20021366. J Exp Med. 2003. PMID: 12682110 Free PMC article. - The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families.
Park SH, Weiss A, Benlagha K, Kyin T, Teyton L, Bendelac A. Park SH, et al. J Exp Med. 2001 Apr 16;193(8):893-904. doi: 10.1084/jem.193.8.893. J Exp Med. 2001. PMID: 11304550 Free PMC article. - Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes.
Lehuen A, Lantz O, Beaudoin L, Laloux V, Carnaud C, Bendelac A, Bach JF, Monteiro RC. Lehuen A, et al. J Exp Med. 1998 Nov 16;188(10):1831-9. doi: 10.1084/jem.188.10.1831. J Exp Med. 1998. PMID: 9815260 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous