The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis - PubMed (original) (raw)

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

N Sommer et al. Nat Med. 1995 Mar.

Abstract

In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) the cytokines tumour necrosis factor-alpha (TNF), lymphotoxin-alpha (LT), and interferon-gamma (IFN-gamma) are of central pathogenetic importance. A therapy capable of stopping neurological deterioration in MS patients is not yet available. Here, we report that rolipram, a selective type IV phosphodiesterase inhibitor, stereospecifically suppresses the production of TNF/LT and less strongly also IFN-gamma in human and rat auto-reactive T cells. Moreover, we show that rolipram is an effective treatment for EAE. Rolipram has extensively been studied in humans for the treatment of depression, but has not yet been marketed. The data presented here identify rolipram as potential therapy for multiple sclerosis and provoke the immediate initiation of clinical trials.

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Comment in

Multiple sclerosis: TNF revisited, with promise.
Raine CS. Raine CS. Nat Med. 1995 Mar;1(3):211-4. doi: 10.1038/nm0395-211. Nat Med. 1995. PMID: 7585035 Review. No abstract available.

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The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis - PubMed (original) (raw)