Ductular hepatocytes - PubMed (original) (raw)
Affiliations
- PMID: 7599440
Review
Ductular hepatocytes
A E Sirica. Histol Histopathol. 1995 Apr.
Abstract
Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate between those of hepatocytes and intrahepatic biliary epithelium. The origin of ductular hepatocytes is controversial, but it has been hypothesized that they may represent a transitional cell stage associated with either (1) a ductular metaplasia of parenchymal hepatocytes into intrahepatic biliary epithelium, (2) a metaplastic conversion of intrahepatic bile duct or ductular epithelium into hepatocytes, or (3) differentiation of a putative liver stem cell along the hepatocyte lineage. Depending on the liver disease state being investigated, evidence is presented to support all three of these possibilities. Of particular interest is the increasing evidence supporting the existence of a facultative pluripotent stem-like cell associated with the intrahepatic biliary tract, which appears capable of differentiating into various gut endoderm-derived cell types, including hepatocytes, small intestinal mucosal cells, and pancreatic acinar cells. Ductular cells of pancreas have also been demonstrated to alter their differentiation commitment under various induced conditions of pancreatic injury and regeneration, so as to give rise to pancreatic hepatocytes. The presence of a putative stem-like cell in liver together with the plasticity exhibited by some hepatocytes and biliary epithelial cells in various forms of severe hepatic and biliary tract injury can have important implications for carcinogenesis and aberrant regenerative responses in liver. In addition, novel in vivo and cell culture models have been developed, which are serving as potentially powerful tools for investigating the effects of specific growth factors, extracellular matrix components, hormones and other agents on the ability of nonparenchymal epithelial liver cell types to differentiate into hepatocyte-like cells.
Similar articles
- [Biliary epithelium, hepatocytes and oval cells].
Housset C. Housset C. Rev Prat. 2000 Dec 1;50(19):2106-11. Rev Prat. 2000. PMID: 11213452 French. - Hepatic stem cells: a review.
Vessey CJ, de la Hall PM. Vessey CJ, et al. Pathology. 2001 May;33(2):130-41. Pathology. 2001. PMID: 11358043 Review. - Development and molecular composition of the hepatic progenitor cell niche.
Vestentoft PS. Vestentoft PS. Dan Med J. 2013 May;60(5):B4640. Dan Med J. 2013. PMID: 23673270 Review. - Identification of bipotential progenitor cells in human liver regeneration.
Haque S, Haruna Y, Saito K, Nalesnik MA, Atillasoy E, Thung SN, Gerber MA. Haque S, et al. Lab Invest. 1996 Nov;75(5):699-705. Lab Invest. 1996. PMID: 8941215
Cited by
- "Small Hepatocytes" in the Liver.
Mitaka T, Ichinohe N, Tanimizu N. Mitaka T, et al. Cells. 2023 Nov 27;12(23):2718. doi: 10.3390/cells12232718. Cells. 2023. PMID: 38067145 Free PMC article. Review. - Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction.
Kamimoto K, Nakano Y, Kaneko K, Miyajima A, Itoh T. Kamimoto K, et al. Commun Biol. 2020 Jun 5;3(1):289. doi: 10.1038/s42003-020-1006-1. Commun Biol. 2020. PMID: 32503996 Free PMC article. - E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells.
Ueberham E, Aigner T, Ueberham U, Gebhardt R. Ueberham E, et al. J Mol Histol. 2007 Aug;38(4):359-68. doi: 10.1007/s10735-007-9098-1. Epub 2007 Jun 29. J Mol Histol. 2007. PMID: 17605082 - Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells.
Krakowski ML, Kritzik MR, Jones EM, Krahl T, Lee J, Arnush M, Gu D, Sarvetnick N. Krakowski ML, et al. Am J Pathol. 1999 Mar;154(3):683-91. doi: 10.1016/S0002-9440(10)65315-1. Am J Pathol. 1999. PMID: 10079246 Free PMC article. - Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development.
Limaye PB, Alarcón G, Walls AL, Nalesnik MA, Michalopoulos GK, Demetris AJ, Ochoa ER. Limaye PB, et al. Lab Invest. 2008 Aug;88(8):865-72. doi: 10.1038/labinvest.2008.56. Epub 2008 Jun 23. Lab Invest. 2008. PMID: 18574450 Free PMC article.