A fungal actin-related protein involved in nuclear migration - PubMed (original) (raw)
. 1995 Jun 10;247(5):583-90.
doi: 10.1007/BF00290350.
Affiliations
- PMID: 7603438
- DOI: 10.1007/BF00290350
A fungal actin-related protein involved in nuclear migration
M J Robb et al. Mol Gen Genet. 1995.
Abstract
The ro-4 mutant of the filamentous fungus Neurospora crassa forms distinctive colonies in which hyphae grow into rope-like aggregates. This unusual morphology coincides with a defect in hyphal nuclear migration. The ro-4 gene was cloned from a cosmid library by complementation of the closely linked pab-2 gene. The deduced 380 amino acid protein is most similar to the vertebrate actin-related protein/centractin. The RO4 protein is not essential for cell viability, and new strains created by inducing point mutations at the ro-4 locus have a phenotype which is very similar to that of the original mutant. This study provides genetic evidence that an actin-related protein plays a role in nuclear motility. Since nuclear motility is believed to be a microtubule-dependent process, the ro-4 gene product may function as a component of the dynactin complex which activates force generation by cytoplasmic dynein.
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