Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma - PubMed (original) (raw)
Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma
R Y Ball et al. Atherosclerosis. 1995.
Abstract
Sections of human atherosclerotic lesions of different stages show that, in early lesions, the acellular lipid core is usually immediately adjacent to the deepest edge of a collection of macrophage foam cells. Advanced lesions with a large lipid core have variable numbers of macrophage foam cells, close to the lateral edges, or shoulders, of the core. In both early and advanced lesions, some of the macrophages nearest the core appear to be dying. Lipid cores contain two materials which in earlier lesions are found only in macrophages, namely ceroid and CD68 antigen, but do not contain recognisable smooth muscle cell actin. It is concluded that death of macrophage foam cells contributes to the origin and slow enlargement of the lipid core. The cause of macrophage death is not yet certain, but is under investigation.
Similar articles
- Foam cell apoptosis and the development of the lipid core of human atherosclerosis.
Hegyi L, Skepper JN, Cary NR, Mitchinson MJ. Hegyi L, et al. J Pathol. 1996 Dec;180(4):423-9. doi: 10.1002/(SICI)1096-9896(199612)180:4<423::AID-PATH677>3.0.CO;2-1. J Pathol. 1996. PMID: 9014864 - A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW. Stary HC, et al. Circulation. 1995 Sep 1;92(5):1355-74. doi: 10.1161/01.cir.92.5.1355. Circulation. 1995. PMID: 7648691 Review. - Phenotype determination of anti-GM3 positive cells in atherosclerotic lesions of the human aorta. Hypothetical role of ganglioside GM3 in foam cell formation.
Bobryshev YV, Lord RS, Golovanova NK, Gracheva EV, Zvezdina ND, Prokazova NV. Bobryshev YV, et al. Biochim Biophys Acta. 2001 Feb 14;1535(2):87-99. doi: 10.1016/s0925-4439(00)00076-4. Biochim Biophys Acta. 2001. PMID: 11341997 - Foam cells and atherogenesis.
Fowler SD, Mayer EP, Greenspan P. Fowler SD, et al. Ann N Y Acad Sci. 1985;454:79-90. doi: 10.1111/j.1749-6632.1985.tb11846.x. Ann N Y Acad Sci. 1985. PMID: 3907470 Review. No abstract available.
Cited by
- Drug screen identifies verteporfin as a regulator of lipid metabolism in macrophage foam cells.
Hoeffner N, Paul A, Goo YH. Hoeffner N, et al. Sci Rep. 2023 Nov 9;13(1):19588. doi: 10.1038/s41598-023-46467-4. Sci Rep. 2023. PMID: 37949969 Free PMC article. - Haemodynamic Effects on the Development and Stability of Atherosclerotic Plaques in Arterial Blood Vessel.
Lei W, Qian S, Zhu X, Hu J. Lei W, et al. Interdiscip Sci. 2023 Dec;15(4):616-632. doi: 10.1007/s12539-023-00576-w. Epub 2023 Jul 7. Interdiscip Sci. 2023. PMID: 37418092 - Membrane Cholesterol Interactions with Proteins in Hypercholesterolemia-Induced Endothelial Dysfunction.
Fancher IS, Levitan I. Fancher IS, et al. Curr Atheroscler Rep. 2023 Sep;25(9):535-541. doi: 10.1007/s11883-023-01127-w. Epub 2023 Jul 7. Curr Atheroscler Rep. 2023. PMID: 37418067 Free PMC article. Review. - Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling.
Zhang X, Evans TD, Chen S, Sergin I, Stitham J, Jeong SJ, Rodriguez-Velez A, Yeh YS, Park A, Jung IH, Diwan A, Schilling JD, Rom O, Yurdagul A, Epelman S, Cho J, Lodhi IJ, Mittendorfer B, Razani B. Zhang X, et al. Circ Res. 2023 Jul 21;133(3):200-219. doi: 10.1161/CIRCRESAHA.122.321542. Epub 2023 Jun 23. Circ Res. 2023. PMID: 37350264 Free PMC article. - miR-126 promotes M1 to M2 macrophage phenotype switching via VEGFA and KLF4.
Shou X, Wang Y, Jiang Q, Chen J, Liu Q. Shou X, et al. PeerJ. 2023 Mar 31;11:e15180. doi: 10.7717/peerj.15180. eCollection 2023. PeerJ. 2023. PMID: 37020848 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources