Signaling through the hematopoietic cytokine receptors - PubMed (original) (raw)
Review
Signaling through the hematopoietic cytokine receptors
J N Ihle et al. Annu Rev Immunol. 1995.
Abstract
Hematopoiesis is regulated through the interaction of a variety of growth factors with specific receptors of the cytokine receptor superfamily. Although lacking catalytic domains, all the receptors couple ligand binding to the rapid induction of protein tyrosine phosphorylation. This is mediated through a novel family of protein tyrosine kinases termed the Janus kinases (Jaks) which associate with the receptors and are activated following ligand binding. Depending upon the cytokine/receptor system, one or more of the four known Jaks (Jak1, Jak2, Jak3, Tyk2) is/are involved. The activated Jaks phosphorylate both themselves and the receptor subunits, creating docking sites for SH2-containing proteins including SHC, which couples receptor engagement to activation of the ras pathway, and HCP, a protein tyrosine phosphatase which negatively affects the response. In addition, the Jaks phosphorylate one or more of a family of signal transducers and activators of transcription (Stats). Phosphorylation of Stats induces their nuclear translocation and DNA-binding activity. Activation of Stats is independent of activation of the ras pathway and represents a novel signaling pathway correlated with mitogenesis.
Similar articles
- Jaks and Stats in signaling by the cytokine receptor superfamily.
Ihle JN, Kerr IM. Ihle JN, et al. Trends Genet. 1995 Feb;11(2):69-74. doi: 10.1016/s0168-9525(00)89000-9. Trends Genet. 1995. PMID: 7716810 Review. - Janus kinases in cytokine signalling.
Ihle JN. Ihle JN. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):159-66. doi: 10.1098/rstb.1996.0012. Philos Trans R Soc Lond B Biol Sci. 1996. PMID: 8650262 Review. - Signaling by the cytokine receptor superfamily: JAKs and STATs.
Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, Silvennoinen O. Ihle JN, et al. Trends Biochem Sci. 1994 May;19(5):222-7. doi: 10.1016/0968-0004(94)90026-4. Trends Biochem Sci. 1994. PMID: 8048164 Review. - Jaks and Stats in cytokine signaling.
Ihle JN, Nosaka T, Thierfelder W, Quelle FW, Shimoda K. Ihle JN, et al. Stem Cells. 1997;15 Suppl 1:105-11; discussion 112. doi: 10.1002/stem.5530150814. Stem Cells. 1997. PMID: 9368330 Review. - Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily.
Ihle JN, Witthuhn BA, Quelle FW, Silvennoinen O, Tang B, Yi T. Ihle JN, et al. Blood Cells. 1994;20(1):65-80; discussion 80-2. Blood Cells. 1994. PMID: 7994062 Review.
Cited by
- Biological Evaluations and Computer-Aided Approaches of Janus Kinases 2 and 3 Inhibitors for Cancer Treatment: A Review.
Vázquez-Jiménez LK, Rivera G, Juárez-Saldivar A, Ortega-Balleza JL, Ortiz-Pérez E, Jaime-Sánchez E, Paz-González A, Lara-Ramírez EE. Vázquez-Jiménez LK, et al. Pharmaceutics. 2024 Sep 4;16(9):1165. doi: 10.3390/pharmaceutics16091165. Pharmaceutics. 2024. PMID: 39339202 Free PMC article. Review. - Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Gardner S, Jin Y, Fyfe PK, Voisin TB, Bellón JS, Pohler E, Piehler J, Moraga I, Bubeck D. Gardner S, et al. Nat Commun. 2024 Mar 7;15(1):2071. doi: 10.1038/s41467-024-46235-6. Nat Commun. 2024. PMID: 38453915 Free PMC article. - Medicinal chemistry perspective of JAK inhibitors: synthesis, biological profile, selectivity, and structure activity relationship.
Maji L, Sengupta S, Purawarga Matada GS, Teli G, Biswas G, Das PK, Panduranga Mudgal M. Maji L, et al. Mol Divers. 2024 Jan 18. doi: 10.1007/s11030-023-10794-5. Online ahead of print. Mol Divers. 2024. PMID: 38236444 Review. - Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases.
Tomasovic LM, Liu K, VanDyke D, Fabilane CS, Spangler JB. Tomasovic LM, et al. BioDrugs. 2024 Mar;38(2):227-248. doi: 10.1007/s40259-023-00635-0. Epub 2023 Nov 24. BioDrugs. 2024. PMID: 37999893 Free PMC article. Review. - JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions.
Sarapultsev A, Gusev E, Komelkova M, Utepova I, Luo S, Hu D. Sarapultsev A, et al. Mol Biomed. 2023 Nov 8;4(1):40. doi: 10.1186/s43556-023-00151-1. Mol Biomed. 2023. PMID: 37938494 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous