Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors - PubMed (original) (raw)

. 1995 Jul 14;269(5221):221-3.

doi: 10.1126/science.7618083.

Affiliations

• PMID: 7618083
• DOI: 10.1126/science.7618083

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

U G Knaus et al. Science. 1995.

Abstract

The Rac guanosine 5'-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related p21-activated kinases (PAKs) were identified as targets of Rac in human neutrophils. Activity of the approximately 65- and approximately 68-kilodalton PAKs was rapidly stimulated by chemoattractants acting through pertussis toxin-sensitive heterotrimeric GTP-binding proteins (G proteins). Native and recombinant PAKs phosphorylated the p47phox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. The action of PAKs during phagocyte activation by G protein-coupled pathways may contribute to regulation of NADPH oxidase activity.

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