Integration of MAP kinase signal transduction pathways at the serum response element - PubMed (original) (raw)
. 1995 Jul 21;269(5222):403-7.
doi: 10.1126/science.7618106.
Affiliations
- PMID: 7618106
- DOI: 10.1126/science.7618106
Integration of MAP kinase signal transduction pathways at the serum response element
A J Whitmarsh et al. Science. 1995.
Abstract
The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK after treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli.
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