The metabotropic glutamate receptors: structure and functions - PubMed (original) (raw)
Review
The metabotropic glutamate receptors: structure and functions
J P Pin et al. Neuropharmacology. 1995 Jan.
Abstract
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.
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