The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin - PubMed (original) (raw)

. 1995 Jul 28;82(2):251-60.

doi: 10.1016/0092-8674(95)90312-7.

M Nativ, P L Campbell, T Sakurai, R Martinez, S Lev, D O Clary, J Schilling, G Barnea, G D Plowman, M Grumet, J Schlessinger

Affiliations

• PMID: 7628014
• DOI: 10.1016/0092-8674(95)90312-7

Free article

The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin

E Peles et al. Cell. 1995.

Free article

Abstract

Receptor-type protein tyrosine phosphatase beta (RPTP beta) is expressed in the developing nervous system and contains a carbonic anhydrase (CAH) domain as well as a fibronectin type III repeat in its extracellular domain. Fusion proteins containing these domains were used to search for ligands of RPTP beta. The CAH domain bound specifically to a 140 kDa protein expressed on the surface of neuronal cells. Expression cloning in COS7 cells revealed that this protein is contactin, a GPI membrane-anchored neuronal cell recognition molecule. The CAH domain of RPTP beta induced cell adhesion and neurite growth of primary tectal neurons, and differentiation of neuroblastoma cells. These responses were blocked by antibodies against contactin, demonstrating that contactin is a neuronal receptor for RPTP beta. These experiments show that an individual domain of RPTP beta acts as a functional ligand for the neuronal receptor contactin. The interaction between contactin and RPTP beta may generate unidirectional or bidirectional signals during neural development.

PubMed Disclaimer

Similar articles

• A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones.
  Parent AS, Mungenast AE, Lomniczi A, Sandau US, Peles E, Bosch MA, Rønnekleiv OK, Ojeda SR. Parent AS, et al. J Neuroendocrinol. 2007 Nov;19(11):847-59. doi: 10.1111/j.1365-2826.2007.01597.x. J Neuroendocrinol. 2007. PMID: 17927663
• Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta.
  Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M. Sakurai T, et al. J Cell Biol. 1997 Feb 24;136(4):907-18. doi: 10.1083/jcb.136.4.907. J Cell Biol. 1997. PMID: 9049255 Free PMC article.
• Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.
  Peles E, Nativ M, Lustig M, Grumet M, Schilling J, Martinez R, Plowman GD, Schlessinger J. Peles E, et al. EMBO J. 1997 Mar 3;16(5):978-88. doi: 10.1093/emboj/16.5.978. EMBO J. 1997. PMID: 9118959 Free PMC article.
• Bidirectional signaling between neurons and glial cells via the F3 neuronal adhesion molecule.
  Revest JM, Faivre-Sarrailh C, Schachner M, Rougon G. Revest JM, et al. Adv Exp Med Biol. 1999;468:309-18. doi: 10.1007/978-1-4615-4685-6_25. Adv Exp Med Biol. 1999. PMID: 10635039 Review.
• Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling.
  Peles E, Schlessinger J, Grumet M. Peles E, et al. Trends Biochem Sci. 1998 Apr;23(4):121-4. doi: 10.1016/s0968-0004(98)01195-5. Trends Biochem Sci. 1998. PMID: 9584610 Review.

Cited by

• Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
  Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, Christianson DW. Whittington DA, et al. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9545-50. doi: 10.1073/pnas.161301298. Epub 2001 Aug 7. Proc Natl Acad Sci U S A. 2001. PMID: 11493685 Free PMC article.
• Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system.
  Lamprianou S, Harroch S. Lamprianou S, et al. J Mol Neurosci. 2006;29(3):241-55. doi: 10.1385/JMN:29:3:241. J Mol Neurosci. 2006. PMID: 17085782 Review.
• Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms.
  Patten BA, Sardi SP, Koirala S, Nakafuku M, Corfas G. Patten BA, et al. J Neurosci. 2006 Mar 22;26(12):3102-8. doi: 10.1523/JNEUROSCI.4829-05.2006. J Neurosci. 2006. PMID: 16554461 Free PMC article.
• Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice.
  Niisato K, Fujikawa A, Komai S, Shintani T, Watanabe E, Sakaguchi G, Katsuura G, Manabe T, Noda M. Niisato K, et al. J Neurosci. 2005 Feb 2;25(5):1081-8. doi: 10.1523/JNEUROSCI.2565.04.2005. J Neurosci. 2005. PMID: 15689543 Free PMC article.
• The Role of the Tumor Suppressor Gene Protein Tyrosine Phosphatase Gamma in Cancer.
  Boni C, Sorio C. Boni C, et al. Front Cell Dev Biol. 2022 Jan 5;9:768969. doi: 10.3389/fcell.2021.768969. eCollection 2021. Front Cell Dev Biol. 2022. PMID: 35071225 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • GlyGen glycoinformatics resource