Modulation of chromatin folding by histone acetylation - PubMed (original) (raw)
. 1995 Jul 28;270(30):17923-8.
doi: 10.1074/jbc.270.30.17923.
Affiliations
- PMID: 7629098
- DOI: 10.1074/jbc.270.30.17923
Free article
Modulation of chromatin folding by histone acetylation
M Garcia-Ramirez et al. J Biol Chem. 1995.
Free article
Abstract
A homogeneous oligonucleosome complex was prepared by reconstitution of highly hyperacetylated histone octamers onto a linear DNA template consisting of 12 tandemly arranged 208-base pair fragments of the 5 S rRNA gene from the sea urchin Lytechinus variegatus. The ionic strength-dependent folding of this oligonucleosome assembly was monitored by sedimentation velocity and electron microscopy. Both types of analysis indicate that under ionic conditions resembling those found in the physiological range and in the absence of histone H1, the acetylated oligonucleosome complexes remain in an extended conformation in contrast to their nonacetylated counterparts. The implications of this finding in the context of a multistate model of chromatin folding (Hansen, J. C., and Ausio, J. (1992) TIBS 197, 187-191) as well as its biological relevance are discussed.
Similar articles
- Role of the histone "tails" in the folding of oligonucleosomes depleted of histone H1.
Garcia-Ramirez M, Dong F, Ausio J. Garcia-Ramirez M, et al. J Biol Chem. 1992 Sep 25;267(27):19587-95. J Biol Chem. 1992. PMID: 1527076 - Folding of chromatin in the presence of heterogeneous histone H1 binding to nucleosomes.
Howe L, Iskandar M, Ausió J. Howe L, et al. J Biol Chem. 1998 May 8;273(19):11625-9. doi: 10.1074/jbc.273.19.11625. J Biol Chem. 1998. PMID: 9565581 - Deposition of histone H1 onto reconstituted nucleosome arrays inhibits both initiation and elongation of transcripts by T7 RNA polymerase.
O'Neill TE, Meersseman G, Pennings S, Bradbury EM. O'Neill TE, et al. Nucleic Acids Res. 1995 Mar 25;23(6):1075-82. doi: 10.1093/nar/23.6.1075. Nucleic Acids Res. 1995. PMID: 7731795 Free PMC article. - Characterization of the stability and folding of H2A.Z chromatin particles: implications for transcriptional activation.
Abbott DW, Ivanova VS, Wang X, Bonner WM, Ausió J. Abbott DW, et al. J Biol Chem. 2001 Nov 9;276(45):41945-9. doi: 10.1074/jbc.M108217200. Epub 2001 Sep 10. J Biol Chem. 2001. PMID: 11551971 - Role of histone acetylation in the assembly and modulation of chromatin structures.
Annunziato AT, Hansen JC. Annunziato AT, et al. Gene Expr. 2000;9(1-2):37-61. doi: 10.3727/000000001783992687. Gene Expr. 2000. PMID: 11097424 Free PMC article. Review.
Cited by
- Role of D(-)-Lactic Acid in Prevention of Chlamydia trachomatis Infection in an In Vitro Model of HeLa Cells.
Zalambani C, Rizzardi N, Marziali G, Foschi C, Morselli S, Djusse ME, Naldi M, Fato R, Calonghi N, Marangoni A. Zalambani C, et al. Pathogens. 2023 Jun 28;12(7):883. doi: 10.3390/pathogens12070883. Pathogens. 2023. PMID: 37513730 Free PMC article. - Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma.
Bitler BG, Bailey CA, Yamamoto TM, McMellen A, Kim H, Watson ZL. Bitler BG, et al. Mol Carcinog. 2023 Nov;62(11):1717-1730. doi: 10.1002/mc.23610. Epub 2023 Jul 26. Mol Carcinog. 2023. PMID: 37493106 Free PMC article. - Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity.
Janczewski Ł. Janczewski Ł. Molecules. 2022 Mar 7;27(5):1750. doi: 10.3390/molecules27051750. Molecules. 2022. PMID: 35268851 Free PMC article. Review. - The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation.
Miao L, Tang Y, Bonneau AR, Chan SH, Kojima ML, Pownall ME, Vejnar CE, Gao F, Krishnaswamy S, Hendry CE, Giraldez AJ. Miao L, et al. Mol Cell. 2022 Mar 3;82(5):986-1002.e9. doi: 10.1016/j.molcel.2022.01.024. Epub 2022 Feb 18. Mol Cell. 2022. PMID: 35182480 Free PMC article. - Quantifying epigenetic modulation of nucleosome breathing by high-throughput AFM imaging.
Konrad SF, Vanderlinden W, Lipfert J. Konrad SF, et al. Biophys J. 2022 Mar 1;121(5):841-851. doi: 10.1016/j.bpj.2022.01.014. Epub 2022 Jan 20. Biophys J. 2022. PMID: 35065917 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous