Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase - PubMed (original) (raw)

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. 1995 Aug 7;369(2-3):136-9.

doi: 10.1016/0014-5793(95)00763-y.

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• PMID: 7649245
• DOI: 10.1016/0014-5793(95)00763-y

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Review

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

G C Brown. FEBS Lett. 1995.

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Abstract

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.

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