Structural determinants of neurotrophin action - PubMed (original) (raw)
Review
. 1995 Aug 25;270(34):19669-72.
doi: 10.1074/jbc.270.34.19669.
Affiliations
- PMID: 7649974
- DOI: 10.1074/jbc.270.34.19669
Free article
Review
Structural determinants of neurotrophin action
N Q McDonald et al. J Biol Chem. 1995.
Free article
Abstract
Five decades of research on NGF have led to the discovery of a small family of evolutionarily conserved proteins, which have vital functions in the survival and neuronal development of specific neuronal populations. The generation of mice lacking neurotrophin expression has recapitulated classic experiments using anti-NGF antibodies to dissect the physiological effects of trophic factor deprivation (73). Very similar outcomes resulted from both the NGF immunodepletion experiments and the transgenic mouse experiments. The genetic results also verify the structural predictions made from binding results in heterologous cells. The findings in cell culture and animal experiments clearly indicate the efficacy of neurotrophic factors for promoting the survival of prominent neuronal populations such as sensory and motor neurons. The high degree of conservation of neurotrophin structure is accompanied by a surprising variation in the amino acid contacts used by each neurotrophin with p75 and the trk receptor family members. It is this variation that may provide specificity for each ligand-receptor complex. The future challenge will be to make use of this knowledge to design effective therapeutic strategies to treat neurodegeneration and nerve injury.
Similar articles
- [Function, molecular structure and gene expression regulation of nerve growth factor].
Furukawa Y. Furukawa Y. Nihon Rinsho. 1992 Aug;50(8):1910-7. Nihon Rinsho. 1992. PMID: 1433983 Review. Japanese. - Differential involvement of metabotropic and p75 neurotrophin receptors in effects of nerve growth factor and neurotrophin-3 on cultured Purkinje cell survival.
Mount HT, Elkabes S, Dreyfus CF, Black IB. Mount HT, et al. J Neurochem. 1998 Mar;70(3):1045-53. doi: 10.1046/j.1471-4159.1998.70031045.x. J Neurochem. 1998. PMID: 9489724 - Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.
Lindsay RM. Lindsay RM. Philos Trans R Soc Lond B Biol Sci. 1996 Mar 29;351(1338):365-73. doi: 10.1098/rstb.1996.0030. Philos Trans R Soc Lond B Biol Sci. 1996. PMID: 8730773 Review. - Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.
Fundin BT, Silos-Santiago I, Ernfors P, Fagan AM, Aldskogius H, DeChiara TM, Phillips HS, Barbacid M, Yancopoulos GD, Rice FL. Fundin BT, et al. Dev Biol. 1997 Oct 1;190(1):94-116. doi: 10.1006/dbio.1997.8658. Dev Biol. 1997. PMID: 9331334 - Effect of p75 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice.
Turner BJ, Murray SS, Piccenna LG, Lopes EC, Kilpatrick TJ, Cheema SS. Turner BJ, et al. J Neurosci Res. 2004 Oct 15;78(2):193-9. doi: 10.1002/jnr.20256. J Neurosci Res. 2004. PMID: 15378612
Cited by
- Development of Neuronal Guidance Fibers for Stimulating Electrodes: Basic Construction and Delivery of a Growth Factor.
Wille I, Harre J, Oehmichen S, Lindemann M, Menzel H, Ehlert N, Lenarz T, Warnecke A, Behrens P. Wille I, et al. Front Bioeng Biotechnol. 2022 Jan 24;10:776890. doi: 10.3389/fbioe.2022.776890. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35141211 Free PMC article. - A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies.
Singh AA, Kharwar A, Dandekar MP. Singh AA, et al. Curr Neuropharmacol. 2022 Aug 3;20(9):1667-1686. doi: 10.2174/1570159X19666210907092928. Curr Neuropharmacol. 2022. PMID: 34493185 Free PMC article. Review. - Neurotrophin Regulation and Signaling in Airway Smooth Muscle.
Roos BB, Teske JJ, Bhallamudi S, Pabelick CM, Sathish V, Prakash YS. Roos BB, et al. Adv Exp Med Biol. 2021;1304:109-121. doi: 10.1007/978-3-030-68748-9_7. Adv Exp Med Biol. 2021. PMID: 34019266 Free PMC article. - hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay.
Triaca V, Fico E, Sposato V, Caioli S, Ciotti MT, Zona C, Mercanti D, La Mendola D, Satriano C, Rizzarelli E, Tirassa P, Calissano P. Triaca V, et al. Biomolecules. 2020 Feb 1;10(2):216. doi: 10.3390/biom10020216. Biomolecules. 2020. PMID: 32024191 Free PMC article. - Long-term delivery of brain-derived neurotrophic factor (BDNF) from nanoporous silica nanoparticles improves the survival of spiral ganglion neurons in vitro.
Schmidt N, Schulze J, Warwas DP, Ehlert N, Lenarz T, Warnecke A, Behrens P. Schmidt N, et al. PLoS One. 2018 Mar 27;13(3):e0194778. doi: 10.1371/journal.pone.0194778. eCollection 2018. PLoS One. 2018. PMID: 29584754 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials