Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination - PubMed (original) (raw)
Review
Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination
R Grosschedl. Curr Opin Cell Biol. 1995 Jun.
Abstract
Regulation of transcription involves the assembly of multiprotein complexes at enhancers and promoters. Interactions between adjacent and non-adjacent DNA-binding proteins can augment the specificity and stability of multi-component nucleoprotein complexes. Recently, several proteins have been identified that can function as 'architectural' elements in the assembly of higher-order nucleoprotein structures reminiscent of those involved in site-specific recombination in prokaryotes.