Complete multipoint sib-pair analysis of qualitative and quantitative traits - PubMed (original) (raw)

Complete multipoint sib-pair analysis of qualitative and quantitative traits

L Kruglyak et al. Am J Hum Genet. 1995 Aug.

Abstract

Sib-pair analysis is an increasingly important tool for genetic dissection of complex traits. Current methods for sib-pair analysis are primarily based on studying individual genetic markers one at a time and thus fail to use the full inheritance information provided by multipoint linkage analysis. In this paper, we describe how to extract the complete multipoint inheritance information for each sib pair. We then describe methods that use this information to map loci affecting traits, thereby providing a unified approach to both qualitative and quantitative traits. Specifically, complete multipoint approaches are presented for (1) exclusion mapping of qualitative traits; (2) maximum-likelihood mapping of qualitative traits; (3) information-content mapping, showing the extent to which all inheritance information has been extracted at each location in the genome; and (4) quantitative-trait mapping, by two parametric methods and one nonparametric method. In addition, we explore the effects of marker density, marker polymorphism, and availability of parents on the information content of a study. We have implemented the analysis methods in a new computer package, MAPMAKER/SIBS. With this computer package, complete multipoint analysis with dozens of markers in hundreds of sib pairs can be carried out in minutes.

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Comment in

• The phenotypic difference discards sib-pair QTL linkage information.
  Wright FA. Wright FA. Am J Hum Genet. 1997 Mar;60(3):740-2. Am J Hum Genet. 1997. PMID: 9042938 Free PMC article. No abstract available.
• Further evidence suggesting the presence of a locus, on human chromosome 5q31-q33, influencing the intensity of infection with Schistosoma mansoni.
  Müller-Myhsok B, Stelma FF, Guissé-Sow F, Muntau B, Thye T, Burchard GD, Gryseels B, Horstmann RD. Müller-Myhsok B, et al. Am J Hum Genet. 1997 Aug;61(2):452-4. doi: 10.1016/S0002-9297(07)64073-7. Am J Hum Genet. 1997. PMID: 9311752 Free PMC article. No abstract available.

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