Lymphadenectomy for gastric cancer in clinical trials: update - PubMed (original) (raw)

Review

. 1995 Jul-Aug;19(4):546-53.

doi: 10.1007/BF00294718.

Affiliations

• PMID: 7676699
• DOI: 10.1007/BF00294718

Review

Lymphadenectomy for gastric cancer in clinical trials: update

J D Roder et al. World J Surg. 1995 Jul-Aug.

Abstract

The controversy over the value of extended lymph node dissection for treatment of gastric cancer is fiercely debated. Whereas Japanese surgeons claim that the superior survival rates in their series are due to extensive resection (D2 resection), many Western authorities believe that their results only reflect differences in the prevalence of prognostic factors, inconsistencies between Japanese and Western staging systems, and the phenomenon of "stage migration," which occurs with extensive resection. Two small randomized prospective trials from Hong Kong and Cape Town showed a tendency toward high morbidity with extensive lymph node dissection but no survival benefit. In contrast, the recently completed prospective German Gastric Carcinoma Study demonstrated a clear survival advantage with D2 resection for tumor stages II and IIIa with no increase in perioperative morbidity or mortality. The long-term results of the still ongoing randomized MRC and Dutch trials are therefore eagerly awaited.

PubMed Disclaimer

Similar articles

• Extended lymphadenectomy in gastric cancer: when, for whom and why.
  Roukos DH. Roukos DH. Ann R Coll Surg Engl. 1998 Jan;80(1):16-24. Ann R Coll Surg Engl. 1998. PMID: 9579122 Free PMC article. Review.
• Resection for gastric cancer in the community.
  van de Velde CJ. van de Velde CJ. Semin Oncol. 2005 Dec;32(6 Suppl 9):S90-3. doi: 10.1053/j.seminoncol.2005.06.010. Semin Oncol. 2005. PMID: 16399441
• [Total gastrectomy for gastric cancer: can the type of lymphadenectomy condition the long-term results?].
  Di Martino N, Izzo G, Cosenza A, Vicenzo L, Monaco L, Torelli F, Basciotti A, Brillantino A, Marra A. Di Martino N, et al. Suppl Tumori. 2005 May-Jun;4(3):S84-5. Suppl Tumori. 2005. PMID: 16437920 Italian.
• Lymph node dissection in resectable advanced gastric cancer.
  de Steur WO, Dikken JL, Hartgrink HH. de Steur WO, et al. Dig Surg. 2013;30(2):96-103. doi: 10.1159/000350873. Epub 2013 Jul 18. Dig Surg. 2013. PMID: 23867585 Review.
• Does extended lymphadenectomy influence prognosis of gastric carcinoma after curative resection?
  Ramacciato G, Aurello P, D'Angelo F, Cicchini C, Sternberg CN. Ramacciato G, et al. Hepatogastroenterology. 2000 Sep-Oct;47(35):1470-4. Hepatogastroenterology. 2000. PMID: 11100379

Cited by

• Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma.
  Strong VE, Song KY, Park CH, Jacks LM, Gonen M, Shah MA, Coit DG, Brennan MF. Strong VE, et al. J Surg Oncol. 2013 May;107(6):634-40. doi: 10.1002/jso.23288. Epub 2012 Nov 28. J Surg Oncol. 2013. PMID: 23192297 Free PMC article. Clinical Trial.
• Aggressive surgical treatment for T4 gastric cancer.
  Kobayashi A, Nakagohri T, Konishi M, Inoue K, Takahashi S, Itou M, Sugitou M, Ono M, Saito N, Kinoshita T. Kobayashi A, et al. J Gastrointest Surg. 2004 May-Jun;8(4):464-70. doi: 10.1016/j.gassur.2003.12.018. J Gastrointest Surg. 2004. PMID: 15120372
• Extended lymphadenectomy is associated with a survival benefit for node-negative gastric cancer.
  Harrison LE, Karpeh MS, Brennan MF. Harrison LE, et al. J Gastrointest Surg. 1998 Mar-Apr;2(2):126-31. doi: 10.1016/s1091-255x(98)80002-4. J Gastrointest Surg. 1998. PMID: 9834407
• Immunocytochemically detected free peritoneal tumour cells (FPTC) are a strong prognostic factor in gastric carcinoma.
  Nekarda H, Gess C, Stark M, Mueller JD, Fink U, Schenck U, Siewert JR. Nekarda H, et al. Br J Cancer. 1999 Feb;79(3-4):611-9. doi: 10.1038/sj.bjc.6690096. Br J Cancer. 1999. PMID: 10027338 Free PMC article.
• Postoperative mortality and morbidity after D2 lymphadenectomy for gastric cancer: A retrospective cohort study.
  Brisinda G, Chiarello MM, Crocco A, Adams NJ, Fransvea P, Vanella S. Brisinda G, et al. World J Gastroenterol. 2022 Jan 21;28(3):381-398. doi: 10.3748/wjg.v28.i3.381. World J Gastroenterol. 2022. PMID: 35110956 Free PMC article.

References

1. 1. Eur J Surg. 1992 Aug;158(8):413-8 - PubMed
2. 1. Ann Surg. 1993 Nov;218(5):583-92 - PubMed
3. 1. Br J Surg. 1988 Feb;75(2):110-2 - PubMed
4. 1. Chirurg. 1993 Dec;64(12):1024-30; discussion 1031 - PubMed
5. 1. Cancer. 1992 Sep 1;70(5):1030-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Medical

  • MedlinePlus Health Information