Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy - PubMed (original) (raw)
Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy
T Yamamoto et al. Proc Natl Acad Sci U S A. 1993.
Abstract
Diabetes is now the most common cause of progressive kidney failure leading to dialysis or transplantation. The central pathological feature of diabetic nephropathy is accumulation of extracellular matrix within the glomeruli. The factors in the diabetic milieu responsible for extracellular matrix accumulation are not understood. Here we report that in glomeruli of rats made diabetic there is a slow, progressive increase in the expression of transforming growth factor beta (TGF-beta) mRNA and TGF-beta protein. A key action of TGF-beta is induction of extracellular matrix production, and specific matrix proteins known to be induced by TGF-beta were increased in diabetic rat glomeruli. These proteins include an alternatively spliced form of fibronectin, tenascin, and the proteoglycan biglycan. TGF-beta has not previously been implicated in the matrix accumulation that occurs in the diabetic kidney. Glomeruli from humans with diabetic nephropathy also showed a striking increase in immunoreactive TGF-beta protein and deposition of the special form of fibronectin, whereas glomeruli from normal subjects or from individuals with other glomerular diseases (where extracellular matrix accumulation is not a feature) were negative or barely positive. These results implicate TGF-beta in the pathogenesis of diabetic nephropathy.
Similar articles
- Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease.
Border WA, Noble NA, Yamamoto T, Harper JR, Yamaguchi Yu, Pierschbacher MD, Ruoslahti E. Border WA, et al. Nature. 1992 Nov 26;360(6402):361-4. doi: 10.1038/360361a0. Nature. 1992. PMID: 1280332 - Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin.
Schaefer L, Raslik I, Grone HJ, Schonherr E, Macakova K, Ugorcakova J, Budny S, Schaefer RM, Kresse H. Schaefer L, et al. FASEB J. 2001 Mar;15(3):559-61. doi: 10.1096/fj.00-0493fje. Epub 2001 Jan 19. FASEB J. 2001. PMID: 11259366 - Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy.
Wang SN, LaPage J, Hirschberg R. Wang SN, et al. Kidney Int. 2000 Mar;57(3):1002-14. doi: 10.1046/j.1523-1755.2000.00928.x. Kidney Int. 2000. PMID: 10720953 - The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy.
Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A, Ziyadeh FN. Chen S, et al. Ren Fail. 2001 May-Jul;23(3-4):471-81. doi: 10.1081/jdi-100104730. Ren Fail. 2001. PMID: 11499562 Review. - Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up.
Chen S, Jim B, Ziyadeh FN. Chen S, et al. Semin Nephrol. 2003 Nov;23(6):532-43. doi: 10.1053/s0270-9295(03)00132-3. Semin Nephrol. 2003. PMID: 14631561 Review.
Cited by
- Imeglimin for Type 2 Diabetes Mellitus: Its Efficacy and Insight Into the Potential Benefit for Renal and Liver Function.
Uto A, Ishinoda Y, Asaga T, Tanahashi Y, Kobayashi A, Meshino H, Okazaki M, Tomita K, Kasuga A, Oshima N. Uto A, et al. Cureus. 2024 Aug 6;16(8):e66322. doi: 10.7759/cureus.66322. eCollection 2024 Aug. Cureus. 2024. PMID: 39238763 Free PMC article. - Targeting the transmembrane cytokine co-receptor neuropilin-1 in distal tubules improves renal injury and fibrosis.
Li Y, Wang Z, Xu H, Hong Y, Shi M, Hu B, Wang X, Ma S, Wang M, Cao C, Zhu H, Hu D, Xu C, Lin Y, Xu G, Yao Y, Zeng R. Li Y, et al. Nat Commun. 2024 Jul 8;15(1):5731. doi: 10.1038/s41467-024-50121-6. Nat Commun. 2024. PMID: 38977708 Free PMC article. - Intrinsic TGF-β signaling attenuates proximal tubule mitochondrial injury and inflammation in chronic kidney disease.
Kayhan M, Vouillamoz J, Rodriguez DG, Bugarski M, Mitamura Y, Gschwend J, Schneider C, Hall A, Legouis D, Akdis CA, Peter L, Rehrauer H, Gewin L, Wenger RH, Khodo SN. Kayhan M, et al. Nat Commun. 2023 Jun 3;14(1):3236. doi: 10.1038/s41467-023-39050-y. Nat Commun. 2023. PMID: 37270534 Free PMC article. - Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Zou TF, Liu ZG, Cao PC, Zheng SH, Guo WT, Wang TX, Chen YL, Duan YJ, Li QS, Liao CZ, Xie ZL, Han JH, Yang XX. Zou TF, et al. Acta Pharmacol Sin. 2023 Oct;44(10):2065-2074. doi: 10.1038/s41401-023-01106-6. Epub 2023 May 24. Acta Pharmacol Sin. 2023. PMID: 37225845 - Inflammatory Networks in Renal Cell Carcinoma.
Kruk L, Mamtimin M, Braun A, Anders HJ, Andrassy J, Gudermann T, Mammadova-Bach E. Kruk L, et al. Cancers (Basel). 2023 Apr 9;15(8):2212. doi: 10.3390/cancers15082212. Cancers (Basel). 2023. PMID: 37190141 Free PMC article. Review.
References
- J Biol Chem. 1986 Apr 5;261(10):4377-9 - PubMed
- J Biol Chem. 1988 Feb 25;263(6):3039-45 - PubMed
- J Exp Med. 1974 Apr 1;139(4):793-800 - PubMed
- Surgery. 1975 Aug;78(2):142-8 - PubMed
- Diabetes. 1976;25(2 SUPPL):850-7 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous