Agrin and the molecular choreography of synapse formation - PubMed (original) (raw)
Review
Agrin and the molecular choreography of synapse formation
M A Nastuk et al. Trends Neurosci. 1993 Feb.
Abstract
High concentrations of neurotransmitter receptors characterize neuromuscular junctions as well as neuron-neuron synapses in the brain and periphery. Synaptic function is critically dependent upon this marshalling of neurotransmitter receptors to the post-synaptic membrane. This review discusses agrin's role in orchestrating the molecular topography of the post-synaptic apparatus at nerve-muscle synapses and the emerging evidence suggesting a role for agrin in synaptogenesis in the brain.
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