Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer - PubMed (original) (raw)

. 1993 Apr;142(4):1019-27.

Affiliations

PMID: 7682757
PMCID: PMC1886885

Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer

L Nikkari et al. Am J Pathol. 1993 Apr.

Abstract

Integrins are heterodimeric cell adhesion receptors. The beta 1 integrin subunit can be in a complex with multiple a subunits and form receptors for collagen, laminin, fibronectin, and vitronectin. We have characterized the distribution of eight integrin subunits in rheumatoid synovium, with special interest in the lining cell layer. The beta 1 integrin subunit was found in abundance in synovial stroma and in lining cells. The only alpha subunit seen constantly in lining cells was alpha 6. In complex with alpha beta subunit, alpha 6 forms a laminin receptor usually seen in epithelial or endothelial cells or in macrophages. The fact that laminin was found in the extracellular matrix around synovial cells suggests the importance of alpha 6 integrin in the adhesion of synovial lining cells. Furthermore, alpha 6 expression was noticeably weaker in strongly proliferative lining cell layers, indicating that the inflammatory process may regulate integrin expression. A potential connection between altered expression of cell adhesion receptors and the pathological behavior of rheumatoid lining cells is suggested.

PubMed Disclaimer

Cited by

Comparison of molecular mechanisms of rheumatoid arthritis and osteoarthritis using gene microarrays.
Li H, Hao Z, Zhao L, Liu W, Han Y, Bai Y, Wang J. Li H, et al. Mol Med Rep. 2016 Jun;13(6):4599-605. doi: 10.3892/mmr.2016.5144. Epub 2016 Apr 15. Mol Med Rep. 2016. PMID: 27082252 Free PMC article.
Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation.
Ah Kioon MD, Asensio C, Ea HK, Uzan B, Cohen-Solal M, Lioté F. Ah Kioon MD, et al. Arthritis Res Ther. 2010;12(5):R190. doi: 10.1186/ar3160. Epub 2010 Oct 14. Arthritis Res Ther. 2010. PMID: 20942979 Free PMC article.
Anchorage on fibronectin via VLA-5 (alpha5beta1 integrin) protects rheumatoid synovial cells from Fas-induced apoptosis.
Kitagawa A, Miura Y, Saura R, Mitani M, Ishikawa H, Hashiramoto A, Yoshiya S, Shiozawa S, Kurosaka M. Kitagawa A, et al. Ann Rheum Dis. 2006 Jun;65(6):721-7. doi: 10.1136/ard.2005.041707. Epub 2005 Oct 25. Ann Rheum Dis. 2006. PMID: 16249227 Free PMC article.
Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens.
Tsubaki T, Arita N, Kawakami T, Shiratsuchi T, Yamamoto H, Takubo N, Yamada K, Nakata S, Yamamoto S, Nose M. Tsubaki T, et al. Arthritis Res Ther. 2005;7(4):R825-36. doi: 10.1186/ar1751. Epub 2005 Apr 25. Arthritis Res Ther. 2005. PMID: 15987484 Free PMC article.
Expression of laminins and their integrin receptors in different conditions of synovial membrane and synovial membrane-like interface tissue.
Konttinen YT, Li TF, Xu JW, Tagaki M, Pirilä L, Silvennoinen T, Santavirta S, Virtanen I. Konttinen YT, et al. Ann Rheum Dis. 1999 Nov;58(11):683-90. doi: 10.1136/ard.58.11.683. Ann Rheum Dis. 1999. PMID: 10531072 Free PMC article.

References

1. J Cell Biol. 1991 Aug;114(4):855-63 - PubMed
1. J Cell Sci. 1990 Jun;96 ( Pt 2):207-17 - PubMed
1. J Biol Chem. 1991 Dec 5;266(34):23505-9 - PubMed
1. Bull Rheum Dis. 1958 Dec;9(4):175-6 - PubMed
1. J Cell Biol. 1962 Aug;14:207-20 - PubMed

Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer - PubMed (original) (raw)