Metalloenzymes, structural motifs, and inorganic models - PubMed (original) (raw)
Review
. 1993 Aug 6;261(5122):701-8.
doi: 10.1126/science.7688141.
Affiliations
- PMID: 7688141
- DOI: 10.1126/science.7688141
Review
Metalloenzymes, structural motifs, and inorganic models
K D Karlin. Science. 1993.
Erratum in
- Science 1993 Dec 3;262(5139):1499
Abstract
Metalloenzymes effect a variety of important chemical transformations, often involving small molecule substrates or products such as molecular oxygen, hydrogen, nitrogen, and water. A diverse array of ions or metal clusters is observed at the active-site cores, but living systems use basic recurring structures that have been modified or tuned for specific purposes. Inorganic chemists are actively involved in the elucidation of the structure, spectroscopy, and mechanism of action of these biological catalysts, in part through a synthetic modeling approach involving biomimetic studies.
Comment on
- Bioinorganic chemistry: a maturing frontier.
Lippard SJ. Lippard SJ. Science. 1993 Aug 6;261(5122):699-700. doi: 10.1126/science.8342037. Science. 1993. PMID: 8342037 No abstract available.
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