The distribution of adhesion molecules in human atherosclerosis - PubMed (original) (raw)
The distribution of adhesion molecules in human atherosclerosis
K M Wood et al. Histopathology. 1993 May.
Abstract
Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molecule-1 (ELAM-1)*, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in human atherosclerotic lesions. Autopsy specimens from abdominal aorta and coronary arteries were obtained from 21 cases within 24 h of death. ELAM-1 and ICAM-1 were consistently expressed by the entire intimal endothelium of normal coronary arteries and also by the intimal endothelium overlying aortic fatty streaks. Both coronary artery and aortic lesions showed strong staining for ICAM-1 on and around macrophages. VCAM-1 was not detected on intimal endothelial cells, but strong staining of adventitial lymphoid aggregates for this molecule was seen. This work suggests a role for ELAM-1 and ICAM-1 in mononuclear cell recruitment during atherogenesis.
Comment in
- The expression of adhesion molecules on endothelial cells in atherosclerosis has a topographic relationship with the underlying inflammatory process.
van der Wal AC, Becker AE, Das PK. van der Wal AC, et al. Histopathology. 1994 Feb;24(2):200-1. Histopathology. 1994. PMID: 8181819 No abstract available.
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