Expression of beta 1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms - PubMed (original) (raw)
Expression of beta 1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms
K J Tomaselli et al. J Neurosci. 1993 Nov.
Abstract
Integrins are heterodimeric receptors that mediate responses of neurons and many other cell types to components of the extracellular matrix. In the present article, we examine the roles of individual integrin receptors expressed by spinal sensory neurons of the dorsal root ganglion (DRG) in mediating interactions with laminin, an extracellular matrix glycoprotein that promotes neurite outgrowth. DRG neurons were shown to express three beta 1 integrins that have been shown in other cell types to function as laminin receptors--high levels of alpha 1 beta 1 and alpha 3 beta 1 and low levels of alpha 6 beta 1. In addition, DRG neurons were shown to express a known fibronectin receptor, alpha 5 beta 1, and an integrin with undefined ligands, alpha 6 beta 4. Function-inhibitory monoclonal antibodies specific for the alpha 1, alpha 2, alpha 3, alpha 5, and alpha 6 integrin subunits were used to determine the roles of individual integrins in mediating neurite outgrowth by DRG neurons on laminin. The results demonstrate that alpha 1 beta 1 and alpha 3 beta 1 function as laminin receptors on these neurons. As many as 18 distinct isoforms of laminin may exist, assembled as heterotrimers containing one each of the different A, B1, or B2 subunit homologs. In the present study, we characterize neurite outgrowth in response to two of these isoforms, the AeB1eB2e isoform and the AmB1eB2e isoform. Results utilizing DRG neurons and a pheochromocytoma cell line (PC12) indicate that these two isoforms exhibit differential selectivities for the alpha 1 beta 1 and alpha 3 beta 1 integrins.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Integrin activation and neurotrophin signaling cooperate to enhance neurite outgrowth in sensory neurons.
Tucker BA, Rahimtula M, Mearow KM. Tucker BA, et al. J Comp Neurol. 2005 Jun 6;486(3):267-80. doi: 10.1002/cne.20518. J Comp Neurol. 2005. PMID: 15844170 - Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation.
Guan W, Puthenveedu MA, Condic ML. Guan W, et al. J Neurosci. 2003 Mar 1;23(5):1781-91. doi: 10.1523/JNEUROSCI.23-05-01781.2003. J Neurosci. 2003. PMID: 12629182 Free PMC article. - Beta 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin.
Venstrom K, Reichardt L. Venstrom K, et al. Mol Biol Cell. 1995 Apr;6(4):419-31. doi: 10.1091/mbc.6.4.419. Mol Biol Cell. 1995. PMID: 7542940 Free PMC article. - Integrin function and regulation in development.
Tarone G, Hirsch E, Brancaccio M, De Acetis M, Barberis L, Balzac F, Retta SF, Botta C, Altruda F, Silengo L. Tarone G, et al. Int J Dev Biol. 2000;44(6):725-31. Int J Dev Biol. 2000. PMID: 11061437 Review. - Neuronal laminins and their cellular receptors.
Powell SK, Kleinman HK. Powell SK, et al. Int J Biochem Cell Biol. 1997 Mar;29(3):401-14. doi: 10.1016/s1357-2725(96)00110-0. Int J Biochem Cell Biol. 1997. PMID: 9202420 Review.
Cited by
- C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair.
Goncalves MB, Wu Y, Clarke E, Grist J, Moehlin J, Mendoza-Parra MA, Hobbs C, Kalindjian B, Fok H, Mander AP, Hassanin H, Bendel D, Täubel J, Mant T, Carlstedt T, Jack J, Corcoran JPT. Goncalves MB, et al. Front Mol Neurosci. 2024 Aug 20;17:1411384. doi: 10.3389/fnmol.2024.1411384. eCollection 2024. Front Mol Neurosci. 2024. PMID: 39228795 Free PMC article. - Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice.
Belardo C, Jebali J, Boccella S, Infantino R, Fusco A, Perrone M, Bonsale R, Manzo I, Iannotta M, Scuteri D, Ferraraccio F, Panarese I, Ferrara G, Guida F, Luongo L, Palazzo E, Srairi-Abid N, Marrakchi N, Maione S. Belardo C, et al. Curr Neuropharmacol. 2024;22(8):1391-1405. doi: 10.2174/1570159X22999231207105743. Curr Neuropharmacol. 2024. PMID: 38073106 Free PMC article. - Integrin ligands block mechanical signal transduction in baroreceptors.
Zhao H, Liu P, Zha X, Zhang S, Cao J, Wei H, Wang M, Huang H, Wang W. Zhao H, et al. Life Sci Alliance. 2022 Dec 20;6(3):e202201785. doi: 10.26508/lsa.202201785. Print 2023 Mar. Life Sci Alliance. 2022. PMID: 36625204 Free PMC article. - Integrins protect sensory neurons in models of paclitaxel-induced peripheral sensory neuropathy.
Shin GJ, Pero ME, Hammond LA, Burgos A, Kumar A, Galindo SE, Lucas T, Bartolini F, Grueber WB. Shin GJ, et al. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2006050118. doi: 10.1073/pnas.2006050118. Proc Natl Acad Sci U S A. 2021. PMID: 33876743 Free PMC article. - Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in Neurons.
Meyer M, Kuffner K, Winter J, Neumann ID, Wetzel CH, Jurek B. Meyer M, et al. Int J Mol Sci. 2020 Mar 23;21(6):2200. doi: 10.3390/ijms21062200. Int J Mol Sci. 2020. PMID: 32209973 Free PMC article.
References
- J Cell Biol. 1988 Sep;107(3):1241-52 - PubMed
- J Cell Biol. 1988 Apr;106(4):1289-97 - PubMed
- Nature. 1989 Mar 16;338(6212):229-34 - PubMed
- Neurosci Lett. 1989 Jan 2;96(1):1-6 - PubMed
- J Biol Chem. 1989 Sep 15;264(26):15642-9 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous