Identification of an alternative CTLA-4 ligand costimulatory for T cell activation - PubMed (original) (raw)
. 1993 Nov 5;262(5135):905-7.
doi: 10.1126/science.7694361.
Affiliations
- PMID: 7694361
- DOI: 10.1126/science.7694361
Identification of an alternative CTLA-4 ligand costimulatory for T cell activation
K S Hathcock et al. Science. 1993.
Abstract
Stimulation of T cell proliferation generally requires two signals: The first signal is provided by the T cell receptor binding to antigen, and the second signal or costimulus is provided by a different receptor-ligand interaction. In mouse and human, the CD28-B7 interaction has been identified as a source of costimulatory signals. We have identified a cell surface molecule (GL1) that is distinct from B7 and abundantly expressed on activated B cells. On activated B cells GL1, rather than B7, is the predominant ligand for the T cell-activation molecule CTLA-4. GL1 provides a critical signal for T cell-dependent responses in vitro and in vivo.
Comment in
- New protein steals the show as 'costimulator' of T cells.
Cohen J. Cohen J. Science. 1993 Nov 5;262(5135):844-5. doi: 10.1126/science.7694360. Science. 1993. PMID: 7694360 No abstract available.
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