Oxidants, antioxidants, and respiratory tract lining fluids - PubMed (original) (raw)
Review
Oxidants, antioxidants, and respiratory tract lining fluids
C E Cross et al. Environ Health Perspect. 1994 Dec.
Abstract
Respiratory tract lining fluids (RTLFs) are a heterogeneous group of substances covering the respiratory tract epithelial cells (RTECs) from nasal mucosa to alveoli. Antioxidant contained in the RTLFs can be expected to provide an initial defense against inhaled environmental toxins. The major antioxidants in RTLF include mucin, uric acid, protein (largely albumin), ascorbic acid, and reduced glutathione (GSH). RTLF antioxidants can be augmented by such processes as transudation/exudation of plasma constituents; RTEC secretory processes, including glandular mucus secretion; and cellular antioxidants derived from lysis of RTECs and of inflammatory cells. The antioxidant composition of RTLFs and their role in modulating normal and pathophysiologic RTEC functions under conditions of oxidative stress are yet to be fully characterized.
Similar articles
- Oxidative stress and antioxidants at biosurfaces: plants, skin, and respiratory tract surfaces.
Cross CE, van der Vliet A, Louie S, Thiele JJ, Halliwell B. Cross CE, et al. Environ Health Perspect. 1998 Oct;106 Suppl 5(Suppl 5):1241-51. doi: 10.1289/ehp.98106s51241. Environ Health Perspect. 1998. PMID: 9788905 Free PMC article. Review. - Antioxidant consumption and repletion kinetics in nasal lavage fluid following exposure of healthy human volunteers to ozone.
Mudway IS, Blomberg A, Frew AJ, Holgate ST, Sandström T, Kelly FJ. Mudway IS, et al. Eur Respir J. 1999 Jun;13(6):1429-38. doi: 10.1183/09031936.99.13614399. Eur Respir J. 1999. PMID: 10445623 Clinical Trial. - Oxidative damage to extracellular fluids by ozone and possible protective effects of thiols.
Van der Vliet A, O'Neil CA, Eiserich JP, Cross CE. Van der Vliet A, et al. Arch Biochem Biophys. 1995 Aug 1;321(1):43-50. doi: 10.1006/abbi.1995.1366. Arch Biochem Biophys. 1995. PMID: 7639534 - Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids.
van der Vliet A, O'Neill CA, Cross CE, Koostra JM, Volz WG, Halliwell B, Louie S. van der Vliet A, et al. Am J Physiol. 1999 Feb;276(2):L289-96. doi: 10.1152/ajplung.1999.276.2.L289. Am J Physiol. 1999. PMID: 9950891 - Simulation of respiratory tract lining fluid for in vitro dissolution study.
Bastola R, Young PM, Das SC. Bastola R, et al. Expert Opin Drug Deliv. 2021 Aug;18(8):1091-1100. doi: 10.1080/17425247.2021.1882991. Epub 2021 Feb 5. Expert Opin Drug Deliv. 2021. PMID: 33504235 Review.
Cited by
- The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection.
Giustarini D, Santucci A, Bartolini D, Galli F, Rossi R. Giustarini D, et al. Redox Biol. 2021 May;41:101902. doi: 10.1016/j.redox.2021.101902. Epub 2021 Feb 17. Redox Biol. 2021. PMID: 33662873 Free PMC article. - Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells.
Pazmandi K, Magyarics Z, Boldogh I, Csillag A, Rajnavolgyi E, Bacsi A. Pazmandi K, et al. Free Radic Biol Med. 2012 Feb 1;52(3):635-645. doi: 10.1016/j.freeradbiomed.2011.11.022. Epub 2011 Dec 8. Free Radic Biol Med. 2012. PMID: 22178414 Free PMC article. - Multiphase Kinetic Modeling of Air Pollutant Effects on Protein Modification and Nitrotyrosine Formation in Epithelial Lining Fluid.
Mishra A, Lelieveld S, Pöschl U, Berkemeier T. Mishra A, et al. Environ Sci Technol. 2023 Aug 29;57(34):12642-12653. doi: 10.1021/acs.est.3c03556. Epub 2023 Aug 17. Environ Sci Technol. 2023. PMID: 37587684 Free PMC article. - Prospects of Vitamin C as an Additive in Plasma of Stored Blood.
Vani R, Soumya R, Carl H, Chandni VA, Neha K, Pankhuri B, Trishna S, Vatsal DP. Vani R, et al. Adv Hematol. 2015;2015:961049. doi: 10.1155/2015/961049. Epub 2015 Aug 9. Adv Hematol. 2015. PMID: 26345502 Free PMC article. - Endogenous Nitric Oxide Can Enhance Oxidative Stress Caused by Air Pollutants and Explain Higher Susceptibility of Individuals with Inflammatory Disorders.
Lelieveld S, Lelieveld J, Mishra A, Daiber A, Pozzer A, Pöschl U, Berkemeier T. Lelieveld S, et al. Environ Sci Technol. 2024 Jan 30;58(4):1823-1831. doi: 10.1021/acs.est.3c07010. Epub 2024 Jan 18. Environ Sci Technol. 2024. PMID: 38235527 Free PMC article.
References
- Am J Respir Cell Mol Biol. 1992 Dec;7(6):557-64 - PubMed
- J Clin Invest. 1992 Dec;90(6):2187-96 - PubMed
- J Biol Chem. 1993 Feb 15;268(5):3120-6 - PubMed
- J Lab Clin Med. 1993 Feb;121(2):257-62 - PubMed
- Eur Respir J. 1993 Feb;6(2):163-5 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical