Identification of hepatitis C virus genotypes among hospitalized patients in British Columbia, Canada - PubMed (original) (raw)

Identification of hepatitis C virus genotypes among hospitalized patients in British Columbia, Canada

M Altamirano et al. J Infect Dis. 1995 Apr.

Abstract

The distribution pattern of hepatitis C virus (HCV) genotypes among patients from British Columbia has been investigated by reverse transcription polymerase chain reaction (PCR) amplification of the 5' noncoding region (NCR) and direct DNA sequencing of the PCR product. The sequence data obtained from the British Columbia isolates were compared with HCV sequences for the NCR obtained from GenBank for the construction of a phylogenetic tree using the GDE program, version 2.2. The data show that in British Columbia there are 7 subtypes distributed among major genotypes 1, 2, and 3. The study also shows a new subtype of genotype 1 that represents 29% of the analyzed cases.

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