Calcium signaling in neurons: molecular mechanisms and cellular consequences - PubMed (original) (raw)

Review

. 1995 Apr 14;268(5208):239-47.

doi: 10.1126/science.7716515.

Affiliations

• PMID: 7716515
• DOI: 10.1126/science.7716515

Review

Calcium signaling in neurons: molecular mechanisms and cellular consequences

A Ghosh et al. Science. 1995.

Abstract

Neuronal activity can lead to marked increases in the concentration of cytosolic calcium, which then functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calmodulin and stimulates the activity of a variety of enzymes, including calcium-calmodulin kinases and calcium-sensitive adenylate cyclases. These enzymes transduce the calcium signal and effect short-term biological responses, such as the modification of synaptic proteins and long-lasting neuronal responses that require changes in gene expression. Recent studies of calcium signal-transduction mechanisms have revealed that, depending on the route of entry into a neuron, calcium differentially affects processes that are central to the development and plasticity of the nervous system, including activity-dependent cell survival, modulation of synaptic strength, and calcium-mediated cell death.

PubMed Disclaimer

Similar articles

• Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
  Bading H, Ginty DD, Greenberg ME. Bading H, et al. Science. 1993 Apr 9;260(5105):181-6. doi: 10.1126/science.8097060. Science. 1993. PMID: 8097060
• Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.
  Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME. Dolmetsch RE, et al. Science. 2001 Oct 12;294(5541):333-9. doi: 10.1126/science.1063395. Science. 2001. PMID: 11598293
• Glutamate receptors and gene induction: signalling from receptor to nucleus.
  Lerea LS. Lerea LS. Cell Signal. 1997 May-Jun;9(3-4):219-26. doi: 10.1016/s0898-6568(96)00134-9. Cell Signal. 1997. PMID: 9218121 Review.
• Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation.
  Wiegert JS, Bading H. Wiegert JS, et al. Cell Calcium. 2011 May;49(5):296-305. doi: 10.1016/j.ceca.2010.11.009. Epub 2010 Dec 15. Cell Calcium. 2011. PMID: 21163523 Review.
• L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons.
  Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. Graef IA, et al. Nature. 1999 Oct 14;401(6754):703-8. doi: 10.1038/44378. Nature. 1999. PMID: 10537109

Cited by

• Optogenetic Control of Calcium Oscillation Waveform Defines NFAT as an Integrator of Calcium Load.
  Hannanta-Anan P, Chow BY. Hannanta-Anan P, et al. Cell Syst. 2016 Apr 27;2(4):283-8. doi: 10.1016/j.cels.2016.03.010. Epub 2016 Apr 27. Cell Syst. 2016. PMID: 27135540 Free PMC article.
• Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens.
  Vu TD, Iwasaki Y, Shigenobu S, Maruko A, Oshima K, Iioka E, Huang CL, Abe T, Tamaki S, Lin YW, Chen CK, Lu MY, Hojo M, Wang HV, Tzeng SF, Huang HJ, Kanai A, Gojobori T, Chiang TY, Sun HS, Li WH, Okada N. Vu TD, et al. PLoS Genet. 2020 Jun 17;16(6):e1008831. doi: 10.1371/journal.pgen.1008831. eCollection 2020 Jun. PLoS Genet. 2020. PMID: 32555673 Free PMC article.
• Calcium entry mediated by GLR3.3, an Arabidopsis glutamate receptor with a broad agonist profile.
  Qi Z, Stephens NR, Spalding EP. Qi Z, et al. Plant Physiol. 2006 Nov;142(3):963-71. doi: 10.1104/pp.106.088989. Epub 2006 Sep 29. Plant Physiol. 2006. PMID: 17012403 Free PMC article.
• Evidence of an agrin receptor in cortical neurons.
  Hilgenberg LG, Hoover CL, Smith MA. Hilgenberg LG, et al. J Neurosci. 1999 Sep 1;19(17):7384-93. doi: 10.1523/JNEUROSCI.19-17-07384.1999. J Neurosci. 1999. PMID: 10460245 Free PMC article.
• Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons.
  Iida N, Namikawa K, Kiyama H, Ueno H, Nakamura S, Hattori S. Iida N, et al. J Neurosci. 2001 Sep 1;21(17):6459-66. doi: 10.1523/JNEUROSCI.21-17-06459.2001. J Neurosci. 2001. PMID: 11517234 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database