Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons - PubMed (original) (raw)
. 1995 Apr 14;268(5208):301-4.
doi: 10.1126/science.7716525.
Affiliations
- PMID: 7716525
- DOI: 10.1126/science.7716525
Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons
J C Magee et al. Science. 1995.
Abstract
Activation of dendritic voltage-gated ion channels by local synaptic input was tested by simultaneous dendrite-attached patch-clamp recordings and whole-cell somatic voltage recordings made from CA1 pyramidal neurons in hippocampal slices. Schaffer collateral stimulation elicited subthreshold excitatory postsynaptic potentials (EPSPs) that opened voltage-gated sodium and calcium channels in the apical dendrites. The EPSP-activated sodium channels opened near the peak of the EPSP, whereas low voltage-activated calcium channels opened near the EPSP peak and during the decay phase. Dendritic high voltage-activated channels required somatic action potential generation or suprathreshold synaptic trains for activation. Dendritic voltage-gated channels are, therefore, likely to participate in dendritic integration of synaptic events.
Comment in
- Dendrites shed their dull image.
Barinaga M. Barinaga M. Science. 1995 Apr 14;268(5208):200-1. doi: 10.1126/science.7536341. Science. 1995. PMID: 7536341 No abstract available.
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