Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype - PubMed (original) (raw)

Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype

G Fontanini et al. Eur J Cancer. 1995.

Abstract

Epidermal growth factor receptor (EGFr) levels were evaluated in paraffin-embedded tumour specimens of non-small cell lung cancer (NSCLC) from 176 patients who underwent surgical resection. The EGFr expression was evaluated by immunocytochemical assay using a monoclonal antibody which recognises the external domain of the receptor. EGFr immunoreactivity was significantly higher in squamous than in non-squamous cell carcinomas (P = 0.0009). Hilar and/or mediastinal nodal involvement was found in 29 of 105 (27.4%) squamous cancers, and in this group of patients, the mean of EGFr positive cells was significantly higher than that of patients without nodal involvement (P = 0.01). No significant correlations were found between the expression of EGFr and other clinicopathological or biological parameters such as T-status, grading, proliferative activity. EGFR is suggested to represent a useful indicator of nodal metastasis in NSCLC.

PubMed Disclaimer

Cited by

Tyrosine kinase receptor expression in thymomas.
Henley JD, Cummings OW, Loehrer PJ Sr. Henley JD, et al. J Cancer Res Clin Oncol. 2004 Apr;130(4):222-4. doi: 10.1007/s00432-004-0545-z. Epub 2004 Feb 5. J Cancer Res Clin Oncol. 2004. PMID: 14762710
Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas.
Volm M, Koomagi R, Kaufmann M, Mattern J, Stammler G. Volm M, et al. Clin Exp Metastasis. 1996 May;14(3):209-14. doi: 10.1007/BF00053893. Clin Exp Metastasis. 1996. PMID: 8674274
Fluorodeoxyglucose positron emission tomography and tumor marker expression in non-small cell lung cancer.
Taylor MD, Smith PW, Brix WK, Wick MR, Theodosakis N, Swenson BR, Kozower BD, Lau CL, Jones DR. Taylor MD, et al. J Thorac Cardiovasc Surg. 2009 Jan;137(1):43-8. doi: 10.1016/j.jtcvs.2008.10.014. J Thorac Cardiovasc Surg. 2009. PMID: 19154901 Free PMC article.
Correlation of EGFR-expression with safety and efficacy outcomes in SQUIRE: a randomized, multicenter, open-label, phase III study of gemcitabine-cisplatin plus necitumumab versus gemcitabine-cisplatin alone in the first-line treatment of patients with stage IV squamous non-small-cell lung cancer.
Paz-Ares L, Socinski MA, Shahidi J, Hozak RR, Soldatenkova V, Kurek R, Varella-Garcia M, Thatcher N, Hirsch FR. Paz-Ares L, et al. Ann Oncol. 2016 Aug;27(8):1573-9. doi: 10.1093/annonc/mdw214. Epub 2016 May 20. Ann Oncol. 2016. PMID: 27207107 Free PMC article. Clinical Trial.
Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).
Suarez Pestana E, Greiser U, Sánchez B, Fernández LE, Lage A, Perez R, Böhmer FD. Suarez Pestana E, et al. Br J Cancer. 1997;75(2):213-20. doi: 10.1038/bjc.1997.36. Br J Cancer. 1997. PMID: 9010029 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- The Lens - Patent Citations Database
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype - PubMed (original) (raw)