Liposome destabilization induced by the HIV-1 fusion peptide effect of a single amino acid substitution - PubMed (original) (raw)
Liposome destabilization induced by the HIV-1 fusion peptide effect of a single amino acid substitution
F B Pereira et al. FEBS Lett. 1995.
Free article
Abstract
The 23-residue synthetic peptide representing the N-terminus of HIV-1 gp41 is known to induce either leakage or fusion of lipid vesicles depending on the experimental conditions. In this paper we report that a polar amino acid substitution V-->E at position 2, known to block gp41 activity in vivo, makes the peptide unable to destabilize and/or fuse membranes. Moreover this variant, unlike the parent peptide, is never found in the membrane-associated beta conformation.
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