Fatty acids enhance vascular alpha-adrenergic sensitivity - PubMed (original) (raw)
Clinical Trial
. 1995 Apr;25(4 Pt 2):774-8.
doi: 10.1161/01.hyp.25.4.774.
Affiliations
- PMID: 7721431
- DOI: 10.1161/01.hyp.25.4.774
Clinical Trial
Fatty acids enhance vascular alpha-adrenergic sensitivity
K T Stepniakowski et al. Hypertension. 1995 Apr.
Abstract
Hypertensive patients are heavier and have a more centralized body fat distribution, which is associated with risk factor clustering and resistance to insulin's actions, including suppression of plasma nonesterified fatty acids. We postulated that abnormalities of nonesterified fatty acids contribute to the increased vascular alpha-adrenergic reactivity and tone observed in our previous studies of obese hypertensive subjects. To test this hypothesis, in two separate protocols 10% Intralipid was infused into a dorsal hand vein with heparin to activate lipoprotein lipase and raise fatty acid levels locally. In protocol 1, the effects of Intralipid/heparin compared with those of 5% dextrose/heparin on dorsal hand vein sensitivity to phenylephrine were assessed by use of the linear variable differential transformer technique in 8 normotensive subjects. In protocol 2, the effects of Intralipid/heparin were compared with those of saline/heparin on hand vein responses to both phenylephrine and angiotensin II in 11 normotensive African American women. Intralipid/heparin reduced the dose of phenylephrine required to produce 50% of the maximal venoconstrictor response from 582 to 137 ng/min (compared with dextrose/heparin, P < .01) in protocol 1 and from 293 to 137 ng/min (compared with saline/heparin, P < .01) in protocol 2. Intralipid/heparin did not significantly alter hand vein responses to angiotensin compared with saline/heparin. These data suggest that abnormalities of nonesterified fatty acids in obese hypertensive patients with risk factor clustering may contribute to their increased neurovascular tone.
Similar articles
- Intralipid enhances alpha1-adrenergic receptor mediated pressor sensitivity.
Haastrup AT, Stepniakowski KT, Goodfriend TL, Egan BM. Haastrup AT, et al. Hypertension. 1998 Oct;32(4):693-8. doi: 10.1161/01.hyp.32.4.693. Hypertension. 1998. PMID: 9774365 Clinical Trial. - Fatty acids enhance neurovascular reflex responses by effects on alpha 1-adrenoceptors.
Stepniakowski KT, Sallee FR, Goodfriend TL, Zhang Z, Egan BM. Stepniakowski KT, et al. Am J Physiol. 1996 Jun;270(6 Pt 2):R1340-6. doi: 10.1152/ajpregu.1996.270.6.R1340. Am J Physiol. 1996. PMID: 8764302 - Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins.
Haastrup A, Gadegbeku CA, Zhang D, Mukhin YV, Greene EL, Jaffa AA, Egan BM. Haastrup A, et al. Hypertension. 2001 Oct;38(4):858-63. doi: 10.1161/hy1001.092615. Hypertension. 2001. PMID: 11641299 Clinical Trial. - Fatty acids augment endothelium-dependent dilation in hand veins by a cyclooxygenase-dependent mechanism.
Stepniakowski KT, Lu G, Davda RK, Egan BM. Stepniakowski KT, et al. Hypertension. 1997 Dec;30(6):1634-9. doi: 10.1161/01.hyp.30.6.1634. Hypertension. 1997. PMID: 9403594 - Fatty acids, not insulin, modulate alpha1-adrenergic reactivity in dorsal hand veins.
Stepniakowski KT, Lu G, Miller GD, Egan BM. Stepniakowski KT, et al. Hypertension. 1997 Nov;30(5):1150-5. doi: 10.1161/01.hyp.30.5.1150. Hypertension. 1997. PMID: 9369269
Cited by
- Molecular Aspects in the Development of Type 2 Diabetes and Possible Preventive and Complementary Therapies.
Simon-Szabó L, Lizák B, Sturm G, Somogyi A, Takács I, Németh Z. Simon-Szabó L, et al. Int J Mol Sci. 2024 Aug 22;25(16):9113. doi: 10.3390/ijms25169113. Int J Mol Sci. 2024. PMID: 39201799 Free PMC article. Review. - The effects of acarbose treatment on cardiovascular risk factors in impaired glucose tolerance and diabetic patients: a systematic review and dose-response meta-analysis of randomized clinical trials.
Zamani M, Nikbaf-Shandiz M, Aali Y, Rasaei N, Zarei M, Shiraseb F, Asbaghi O. Zamani M, et al. Front Nutr. 2023 Aug 1;10:1084084. doi: 10.3389/fnut.2023.1084084. eCollection 2023. Front Nutr. 2023. PMID: 37599681 Free PMC article. - Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?
Rodean IP, Biriș CI, Halațiu VB, Modiga A, Lazăr L, Benedek I, Benedek T. Rodean IP, et al. Life (Basel). 2021 Oct 7;11(10):1050. doi: 10.3390/life11101050. Life (Basel). 2021. PMID: 34685421 Free PMC article. Review. - Uncontrolled hypertension in patients with type 2 diabetes: What are the correlates?
Rabizadeh S, Gholami B, Mahmoudzadeh Kani S, Rajab A, Farrokhpour H, Esteghamati A, Nakhjavani M. Rabizadeh S, et al. J Clin Hypertens (Greenwich). 2021 Sep;23(9):1776-1785. doi: 10.1111/jch.14352. Epub 2021 Aug 21. J Clin Hypertens (Greenwich). 2021. PMID: 34418281 Free PMC article. - Acute physical and mental stress resulted in an increase in fatty acids, norepinephrine, and hemodynamic changes in normal individuals: A possible pathophysiological mechanism for hypertension-Pilot study.
Motta E Motta J, Souza LN, Vieira BB, Delle H, Consolim-Colombo FM, Egan BM, Lopes HF. Motta E Motta J, et al. J Clin Hypertens (Greenwich). 2021 Apr;23(4):888-894. doi: 10.1111/jch.14190. Epub 2021 Jan 29. J Clin Hypertens (Greenwich). 2021. PMID: 33512748 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical