Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c mice - PubMed (original) (raw)
Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c mice
A Piona et al. Scand J Immunol. 1995 May.
Abstract
In the present study we evaluated the effect of passive transfer of a mouse monoclonal (CAM) or a human polyclonal anti-cardiolipin IgG on pregnancy outcome in BALB/c mice. The mice were immunized through the tail vein immediately after mating with 10 micrograms of monoclonal or polyclonal anti-cardiolipin antibodies. Two other groups of mice were given a mouse irrelevant monoclonal antibody or normal human polyclonal IgG respectively, at the same dose. In mice immunized with monoclonal or polyclonal anti-cardiolipin antibody we observed a significant increase in the number of fetal resorptions and a significant reduction of the mean weights of the embryos and the placentas. In mice immunized with CAM we also found a significant decrease in the number of healthy pups, while mice infused with human aCL antibody expressed a significant reduction in the fecundity rate. The histological examination showed widespread thrombosis and necrosis in the placentas derived from the mice immunized with the anti-cardiolipin antibodies. The model supports a possible direct pathogenetic effect of anti-phospholipid antibodies in recurrent fetal loss and points out that thrombotic events at placental level can be instrumental in the pathogenesis of the obstetric complications.
Similar articles
- Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies.
Blank M, Cohen J, Toder V, Shoenfeld Y. Blank M, et al. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3069-73. doi: 10.1073/pnas.88.8.3069. Proc Natl Acad Sci U S A. 1991. PMID: 2014226 Free PMC article. - Induction of experimental anti-phospholipid syndrome associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype.
Blank M, Krause I, Ben-Bassat M, Shoenfeld Y. Blank M, et al. J Autoimmun. 1992 Aug;5(4):495-509. doi: 10.1016/0896-8411(92)90008-e. J Autoimmun. 1992. PMID: 1418290 - Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice.
Ikematsu W, Luan FL, La Rosa L, Beltrami B, Nicoletti F, Buyon JP, Meroni PL, Balestrieri G, Casali P. Ikematsu W, et al. Arthritis Rheum. 1998 Jun;41(6):1026-39. doi: 10.1002/1529-0131(199806)41:6<1026::AID-ART9>3.0.CO;2-1. Arthritis Rheum. 1998. PMID: 9627012 - A unique preliminary study on placental apoptosis in mice with passive immunization of anti-phosphatidylethanolamine antibodies and anti-factor XII antibodies.
Velayuthaprabhu S, Matsubayashi H, Sugi T, Nakamura M, Ohnishi Y, Ogura T, Tomiyama T, Archunan G. Velayuthaprabhu S, et al. Am J Reprod Immunol. 2011 Nov;66(5):373-84. doi: 10.1111/j.1600-0897.2011.01008.x. Epub 2011 May 27. Am J Reprod Immunol. 2011. PMID: 21623987 - The role of beta 2-glycoprotein I-dependent lupus anticoagulants in the pathogenesis of the antiphospholipid syndrome.
Arnout J. Arnout J. Verh K Acad Geneeskd Belg. 2000;62(5):353-72. Verh K Acad Geneeskd Belg. 2000. PMID: 11144685 Review.
Cited by
- Placental damage in pregnancies with systemic lupus erythematosus: A narrative review.
Castellanos Gutierrez AS, Figueras F, Morales-Prieto DM, Schleußner E, Espinosa G, Baños N. Castellanos Gutierrez AS, et al. Front Immunol. 2022 Aug 17;13:941586. doi: 10.3389/fimmu.2022.941586. eCollection 2022. Front Immunol. 2022. PMID: 36059466 Free PMC article. Review. - Meant to B: B cells as a therapeutic target in systemic lupus erythematosus.
Atisha-Fregoso Y, Toz B, Diamond B. Atisha-Fregoso Y, et al. J Clin Invest. 2021 Jun 15;131(12):e149095. doi: 10.1172/JCI149095. J Clin Invest. 2021. PMID: 34128474 Free PMC article. Review. - Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications.
Tedesco F, Borghi MO, Gerosa M, Chighizola CB, Macor P, Lonati PA, Gulino A, Belmonte B, Meroni PL. Tedesco F, et al. Front Immunol. 2018 Jun 19;9:1388. doi: 10.3389/fimmu.2018.01388. eCollection 2018. Front Immunol. 2018. PMID: 29971066 Free PMC article. - Female Infertility and Serum Auto-antibodies: a Systematic Review.
Deroux A, Dumestre-Perard C, Dunand-Faure C, Bouillet L, Hoffmann P. Deroux A, et al. Clin Rev Allergy Immunol. 2017 Aug;53(1):78-86. doi: 10.1007/s12016-016-8586-z. Clin Rev Allergy Immunol. 2017. PMID: 27628237 Review. - Complement activation and pregnancy failure.
Tincani A, Cavazzana I, Ziglioli T, Lojacono A, De Angelis V, Meroni P. Tincani A, et al. Clin Rev Allergy Immunol. 2010 Dec;39(3):153-9. doi: 10.1007/s12016-009-8183-5. Clin Rev Allergy Immunol. 2010. PMID: 19936969 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical