Sequence-dependent bending propensity of DNA as revealed by DNase I: parameters for trinucleotides - PubMed (original) (raw)

Comparative Study

Sequence-dependent bending propensity of DNA as revealed by DNase I: parameters for trinucleotides

I Brukner et al. EMBO J. 1995.

Abstract

Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.

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